Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
361-03-012 ISMRM Abstract

Exploring cerebral hemodynamics in extremely preterm infants using 7T 4D Flow MRI

Primary: Pediatrics - Neonatal
Secondary: Contrast Mechanisms - Velocity/Flow
361-03-012 · Thermometry and Other Contrast Mechanisms · Monday, 11 May, 1:50 PM–2:45 PM · Digital Posters Row B
Keywords: 4D flow MRI 7 Tesla Cerebral hemodynamics Preterm infants
Accepted
Nandita Lala1,2, Inge van Ooijen1,2, Lynn Grimberg1, Lieke van den Wildenberg1, Eric Schrauben3, Jeroen Dudink2, Maria Luisa Tataranno2, Niek E van der Aa2, Fredy Visser4, Dennis Klomp1, Jaco J Zwanenburg5, Manon J Benders2, Jannie Wijnen1,6, Evita C Wiegers 1
1Department of Radiology, Centre for Image Sciences, UMC Utrecht, Utrecht, Netherlands
2Department of Neonatology, UMC Utrecht, Utrecht, Netherlands
3Department of Radiology & Nuclear Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
4Philips Healthcare, Best, Netherlands
5Translational Neuroimaging Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands
6Department of Pediatric Neuro-Oncology, Princes Máxima Center for Pediatric Oncology, Netherlands
Presenting Author: Evita C Wiegers

Synopsis

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References

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2. Inder TE, Volpe JJ. Mechanisms of perinatal brain injury. Semin Neonatol. 2000;5(1):3–16.
3. Malamateniou C, Counsell SJ, Allsop JM, et al. The effect of preterm birth on neonatal cerebral vasculature studied with MR angiography at 3 Tesla. NeuroImage. 2006;32(3):1050–1059.
4. Malamateniou C, Adams ME, Srinivasan L, et al. The anatomic variations of the Circle of Willis in preterm-at-term and term-born infants: an MR angiography study at 3T. AJNR Am J Neuroradiol. 2009;30(10):1955–1962.
5. Wagenaar N, Rijsman LH, Nieuwets A, Groenendaal F. Cerebral blood flow measured by phase-contrast MR angiography in preterm and term neonates. Neonatology. 2019;115(3):226–233.
6. Ladd ME, Bachert P, Meyerspeer M, et al. Pros and cons of ultra-high-field MRI/MRS for human application. Prog Nucl Magn Reson Spectrosc. 2018;109:1–50.
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8. ack SA, Riddle A, McClure MM. Maturation-dependent vulnerability of perinatal white matter in premature birth. Stroke. 2007;38(2):724–730.
9. Volpe JJ. Dysmaturation of premature brain: importance, cellular mechanisms, and potential interventions. Pediatr Neurol. 2019;95:42–66.
10. Kidokoro H, Neil JJ, Inder TE. New MR imaging assessment tool to define brain abnormalities in very preterm infants at term. AJNR Am J Neuroradiol. 2013;34(11):2208–2214.
11. Marshall I, Papathanasopoulou P, Wartolowska K. Carotid flow rates and flow division at the bifurcation in healthy volunteers. Physiol Meas. 2004;25(3):691-697.
12. Tanaka H, Fujita N, Enoki T, et al. Relationship between variations in the circle of Willis and flow rates in internal carotid and basilar arteries determined by magnetic resonance imaging with semiautomated lumen segmentation: Reference data from 125 healthy volunteers. AJNR Am J Neuroradiol. 2006;27(8):1770-1775.
13. Zarrinkoob L, Ambarki K, Wåhlin A, et al. Aging alters the dampening of pulsatile blood flow in cerebral arteries. J Cereb Blood Flow Metab. 2016;36(9):1519-1527.
14. Zarrinkoob L, Ambarki K, Wåhlin A, Birgander R, Eklund A, Malm J. Blood flow distribution in cerebral arteries. J Cereb Blood Flow Metab. 2015;35(4):648-654.
15. Brew N, Walker D, Wong FY. Cerebral vascular regulation and brain injury in preterm infants. Am J Physiol Regul Integr Comp Physiol. 2014;306(11):R773–R786.
16. Wåhlin A, Eklund A, Malm J. 4D Flow MRI hemodynamic biomarkers for cerebrovascular diseases. J Intern Med. 2021;291(2):115–127.
17. Van Vuuren AJ, Saling M, Rogerson S, et al. Cerebral arterial asymmetries in the neonate: insight into the pathogenesis of stroke. Symmetry. 2022;14(3):456.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/361-03-012