Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
570-07-212 ISMRM Abstract

Hemodynamic delay correction in breath-hold BOLD fMRI critically alters cerebrovascular reactivity interpretation in stroke

Primary: Brain Function and fMRI - fMRI Analysis
Secondary: Neuro - Stroke and Cerebrovascular Disorders
570-07-212 · Imaging Cerebrovascular Physiology in Stroke and Cerebral Arteriopathies · Wednesday, 13 May, 4:00 PM–4:55 PM · Traditional Posters | Exhibition Hall
Keywords: Stroke Cerebrovascular reactivity BOLD-fMRI Breath-hold Delay Correction
Accepted
Rebecca G Clements 1,2, Fatemeh Geranmayeh3,4, Niamh V Parkinson3,4, Molly Bright1,2,5,6
1Biomedical Engineering, Northwestern University, Chicago, United States of America
2Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, United States of America
3Department of Brain Sciences, Imperial College, London, United Kingdom
4NHS Trust, Imperial College Healthcare, United Kingdom
5Northwestern University, Chicago, United States of America
6Physical Therapy and Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, United States of America
Presenting Author: Rebecca G Clements

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. van Niftrik CHB, Sebök M, Germans MR, et al. Increased Risk of Recurrent Stroke in Symptomatic Large Vessel Disease With Impaired BOLD Cerebrovascular Reactivity. Stroke. 2024;55(3):613-621. doi:10.1161/strokeaha.123.044259 [doi]
2. Geranmayeh F, Wise RJS, Leech R, Murphy K. Measuring vascular reactivity with breath-holds after stroke: A method to aid interpretation of group-level BOLD signal changes in longitudinal fMRI studies. Hum Brain Mapp. 2015;36(5):1755-1771. doi:10.1002/HBM.22735 [doi]
3. Krishnamurthy V, Sprick JD, Krishnamurthy LC, et al. The Utility of Cerebrovascular Reactivity MRI in Brain Rehabilitation: A Mechanistic Perspective. Front Physiol. 2021;12(2):642850. doi:10.3389/FPHYS.2021.642850 [doi]
4. Stickland RC, Zvolanek KM, Moia S, Ayyagari A, Caballero-Gaudes C, Bright MG. A practical modification to a resting state fMRI protocol for improved characterization of cerebrovascular function. Neuroimage. 2021;239:118306. doi:10.1016/J.NEUROIMAGE.2021.118306 [doi]
5. Moia S, Stickland RC, Ayyagari A, Termenon M, Caballero-Gaudes C, Bright MG. Voxelwise optimization of hemodynamic lags to improve regional CVR estimates in breath-hold fMRI. In: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol 2020-July. Institute of Electrical and Electronics Engineers Inc.; 2020:1489-1492. doi:10.1109/EMBC44109.2020.9176225 [doi]
6. Khalil AA, Villringer K, Filleböck V, et al. Non-invasive monitoring of longitudinal changes in cerebral hemodynamics in acute ischemic stroke using BOLD signal delay. Journal of Cerebral Blood Flow and Metabolism. 2020;40(1):23-34. doi:10.1177/0271678X18803951/ASSET/IMAGES/LARGE/10.1177_0271678X18803951-FIG6.JPEG [doi]
7. Amemiya S, Kunimatsu A, Saito N, Ohtomo K. Impaired hemodynamic response in the ischemic brain assessed with BOLD fMRI. Neuroimage. 2012;61(3):579-590. doi:10.1016/J.NEUROIMAGE.2012.04.001 [doi]
8. Lv Y, Margulies DS, Cameron Craddock R, et al. Identifying the perfusion deficit in acute stroke with resting-state functional magnetic resonance imaging. Ann Neurol. 2013;73(1):136-140. doi:10.1002/ANA.23763 [doi]
9. DuPre E, Salo T, Ahmed Z, et al. TE-dependent analysis of multi-echo fMRI with *tedana*. J Open Source Softw. 2021;6(66):3669. doi:10.21105/JOSS.03669 [doi]
10. Moia S, Vigotsky AD, Zvolanek KM. phys2cvr: A tool to compute Cerebrovascular Reactivity maps and associated lag maps. Preprint posted online June 1, 2024. doi:10.5281/ZENODO.7336002 [doi]
11. Jenkinson M, Beckmann CF, Behrens TEJ, Woolrich MW, Smith SM. FSL. Neuroimage. 2012;62(2):782-790. doi:10.1016/J.NEUROIMAGE.2011.09.015 [doi]
12. Poublanc J, Han JS, Mandell DM, et al. Vascular Steal Explains Early Paradoxical Blood Oxygen Level-Dependent Cerebrovascular Response in Brain Regions with Delayed Arterial Transit Times. Cerebrovasc Dis Extra. 2013;3(1):55. doi:10.1159/000348841 [doi]
13. Donahue MJ, Strother MK, Lindsey KP, Hocke LM, Tong Y, Frederick BD. Time delay processing of hypercapnic fMRI allows quantitative parameterization of cerebrovascular reactivity and blood flow delays. Journal of Cerebral Blood Flow and Metabolism. 2015;36(10). doi:10.1177/0271678X15608643 [doi]
14. Šidák Z. Rectangular Confidence Regions for the Means of Multivariate Normal Distributions. J Am Stat Assoc. 1967;62(318):626-633. doi:10.1080/01621459.1967.10482935 [doi]
15. Bright MG, Tench CR, Murphy K. Potential pitfalls when denoising resting state fMRI data using nuisance regression. Neuroimage. 2017;154:159-168. doi:10.1016/J.NEUROIMAGE.2016.12.027 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/570-07-212