Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
463-02-005 ISMRM Abstract

DTI-Based Lesion Subtypes and Penumbra Zones in Ischemic Stroke Treated with Intranasal Stem Cell Therapy

Primary: Diffusion - DWI/DTI/DKI
Secondary: Neuro - Stroke and Cerebrovascular Disorders
463-02-005 · Imaging Stroke Recovery: From Microstructure to Personalized Therapy · Tuesday, 12 May, 9:15 AM–10:10 AM · Digital Posters Row D
Keywords: Diffusion Tensor Imaging Ischemic Stroke Neural stem cell Endonasal Submucosal Hemi-infarct zone
Accepted
Yunlin Peng 1, Danhong Dong2, 方仪 王3, Qiyang Chen3, Liyan Tang4, Diyuan Deng3, Zhehao Wu3, Qinglei Shi5, Renzhi Wang6, Xiang Wan7, Hsien-Da Huang6, Xinjie Bao8
1School of Science and Engineering, The Chinese University of Hong Kong (Shenzhen), Shenzhen Research Institute of Big Data, China
2School of Medicine, The Chinese University of Hong Kong, Shenzhen, Warshel Institute for Computational Biology, China
3School of Data Science, The Chinese University of Hong Kong, Shenzhen, China
4School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, China
5School of Medicine, The Chinese University of Hong Kong (Shenzhen), Shenzhen Research Institute of Big Data, China
6School of Medicine, The Chinese University of Hong Kong, Shenzhen, China
7henzhen Research Institute of Big Data, China
8Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China
Presenting Author: Yunlin Peng

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. GBD 2017 US Neurological Disorders Collaborators. Burden of Neurological Disorders Across the US From 1990-2017: A Global Burden of Disease Study. JAMA Neurol. 2021;78(2):165–176. doi:10.1001/jamaneurol.2020.4152 [doi]
2. Liu, J., Xu, A., Zhao, Z. et al. Epidemiology and future trend predictions of ischemic stroke based on the global burden of disease study 1990–2021. Commun Med 5, 273 (2025). https://doi.org/10.1038/s43856-025-00939-y [doi]
3. Ho JP, Powers WJ. Contemporary Management of Acute Ischemic Stroke. Annu Rev Med. 2025 Jan;76(1):417-429. doi: 10.1146/annurev-med-050823-094312. Epub 2025 Jan 16. PMID: 39496213. [doi] [pmid]
4. Sharma R, Lee K. Advances in treatments for acute ischemic stroke. BMJ. 2025 May 7;389:e076161. doi: 10.1136/bmj-2023-076161. PMID: 40335091. [doi] [pmid]
5. Yan S, Zhou Y, Lansberg MG, Liebeskind DS, Yuan C, Yu H, Chen F, Chen H, Zhang B, Mao L, Zhang X, Wang X, Zhang X, Chen Y, Zhou H, Zhong W, He Y, Chen K, Wang J, Chen H, Huang Y, Campbell BCV, Lou M; EXPECTS Group. Alteplase for Posterior Circulation Ischemic Stroke at 4.5 to 24 Hours. N Engl J Med. 2025 Apr 3;392(13):1288-1296. doi: 10.1056/NEJMoa2413344. PMID: 40174223. [doi] [pmid]
6. Burns TC, Quinones-Hinojosa A. Regenerative medicine for neurological diseases-will regenerative neurosurgery deliver? BMJ. 2021 Jun 23;373:n955. doi: 10.1136/bmj.n955. PMID: 34162530. [doi] [pmid]
7. Sun Y, Jiang X, Gao J. Stem cell-based ischemic stroke therapy: Novel modifications and clinical challenges. Asian J Pharm Sci. 2024 Feb;19(1):100867. doi: 10.1016/j.ajps.2023.100867. Epub 2023 Nov 10. PMID: 38357525; PMCID: PMC10864855. [doi] [pmid]
8. Zhou X, Deng X, Liu M, He M, Long W, Xu Z, Zhang K, Liu T, So KF, Fu QL, Zhou L. Intranasal delivery of BDNF-loaded small extracellular vesicles for cerebral ischemia therapy. J Control Release. 2023 May;357:1-19. doi: 10.1016/j.jconrel.2023.03.033. Epub 2023 Mar 28. PMID: 36958402. [doi] [pmid]
9. Baak, L. M., Wagenaar, N., van der Aa, N. E., Groenendaal, F., Dudink, J., Tataranno, M. L., Mahamuud, U., Verhage, C. H., Eijsermans, R. M. J. C., Smit, L. S., Jellema, R. K., de Haan, T. R., ter Horst, H. J., de Boode, W. P., Steggerda, S. J., Prins, H. J., de Haar, C. G., de Vries, L. S., van Bel, F., ... Benders, M. J. N. L. (2022). Feasibility and safety of intranasally administered mesenchymal stromal cells after perinatal arterial ischaemic stroke in the Netherlands (PASSIoN): a first-in-human, open-label intervention study. The Lancet Neurology, 21(6), 528-536. https://doi.org/10.1016/S1474-4422(22)00117-X [doi]
10. Wagenaar N, Baak LM, van der Aa NE, Groenendaal F, Dudink J, Tataranno ML, Koopman C, Verhage CH, Eijsermans RMJC, van Teeseling HC, Smit LS, Jellema RK, de Haan TR, Ter Horst HJ, de Boode WP, Steggerda SJ, Mulder-de Tollenaer SM, Dijkman KP, de Haar CG, de Vries LS, van Bel F, Heijnen CJ, Nijboer CH, Benders MJNL. Perinatal Arterial Stroke Treated With Stromal Cells Intranasally: 2-Year Safety and Neurodevelopment. Stroke. 2025 Sep;56(9):2410-2418. doi: 10.1161/STROKEAHA.125.050786. Epub 2025 Jul 14. PMID: 40654084; PMCID: PMC12372720. [doi] [pmid]
11. Assaf Y, Pasternak O. Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review. J Mol Neurosci. 2008;34(1):51-61. doi: 10.1007/s12031-007-0029-0. PMID: 18157658. [doi] [pmid]
12. Benjamini D, Priemer DS, Perl DP, Brody DL, Basser PJ. Mapping astrogliosis in the individual human brain using multidimensional MRI. Brain. 2023 Mar 1;146(3):1212-1226. doi: 10.1093/brain/awac298. PMID: 35953450; PMCID: PMC9976979. [doi] [pmid]
13. Genc S, Ball G, Chamberland M, Raven EP, Tax CM, Ward I, Yang JY, Palombo M, Jones DK. MRI signatures of cortical microstructure in human development align with oligodendrocyte cell-type expression. bioRxiv [Preprint]. 2024 Jul 30:2024.07.30.605934. doi: 10.1101/2024.07.30.605934. Update in: Nat Commun. 2025 Apr 7;16(1):3317. doi: 10.1038/s41467-025-58604-w. PMID: 39131383; PMCID: PMC11312524. [doi] [pmid]
14. Spotorno N, Strandberg O, Stomrud E, Janelidze S, Blennow K, Nilsson M, van Westen D, Hansson O. Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer's disease. Brain. 2024 Mar 1;147(3):961-969. doi: 10.1093/brain/awad428. PMID: 38128551; PMCID: PMC10907088. [doi] [pmid]
15. Kuo DP, Chen YC, Li YT, Cheng SJ, Hsieh KL, Kuo PC, Ou CY, Chen CY. Estimating the volume of penumbra in rodents using DTI and stack-based ensemble machine learning framework. Eur Radiol Exp. 2024 May 15;8(1):59. doi: 10.1186/s41747-024-00455-z. PMID: 38744784; PMCID: PMC11093947. [doi] [pmid]
16. Kuo DP, Lu CF, Liou M, Chen YC, Chung HW, Chen CY. Differentiation of the Infarct Core from Ischemic Penumbra within the First 4.5 Hours, Using Diffusion Tensor Imaging-Derived Metrics: A Rat Model. Korean J Radiol. 2017 Mar-Apr;18(2):269-278. doi: 10.3348/kjr.2017.18.2.269. Epub 2017 Feb 7. PMID: 28246507; PMCID: PMC5313515. [doi] [pmid]
17. Chiu FY, Kuo DP, Chen YC, Kao YC, Chung HW, Chen CY. Diffusion Tensor-Derived Properties of Benign Oligemia, True "at Risk" Penumbra, and Infarct Core during the First Three Hours of Stroke Onset: A Rat Model. Korean J Radiol. 2018 Nov-Dec;19(6):1161-1171. doi: 10.3348/kjr.2018.19.6.1161. Epub 2018 Oct 18. PMID: 30386147; PMCID: PMC6201972. [doi] [pmid]
18. Kuo DP, Kuo PC, Chen YC, Kao YJ, Lee CY, Chung HW, Chen CY. Machine learning-based segmentation of ischemic penumbra by using diffusion tensor metrics in a rat model. J Biomed Sci. 2020 Jul 15;27(1):80. doi: 10.1186/s12929-020-00672-9. PMID: 32664906; PMCID: PMC7362663. [doi] [pmid]
19. Nael K, Trouard TP, Lafleur SR, Krupinski EA, Salamon N, Kidwell CS. White matter ischemic changes in hyperacute ischemic stroke: voxel-based analysis using diffusion tensor imaging and MR perfusion. Stroke. 2015 Feb;46(2):413-8. doi: 10.1161/STROKEAHA.114.007000. Epub 2014 Dec 18. PMID: 25523053; PMCID: PMC4306535. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/463-02-005