Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
362-06-003 ISMRM Abstract

Aging Effects on Nigrostriatal Structure, Hemodynamics, and Connectivity: Implications for Parkinson’s Disease

Primary: Neuro - Aging
Secondary: Neuro - Parkinson's Disease
362-06-003 · Neuroimaging Biomarkers of Aging, Vascular Health, and Dementia · Monday, 11 May, 5:05 PM–6:00 PM · Digital Posters Row C
Keywords: Aging Parkinson's Disease Magnetic resonance imaging Hemodynamics Nigrostriatal
Accepted
Jiaqi Wen1, Chenyang Li1, Li Jiang1, Huize Pang1, Toby Nguyen1, Xiaojun Xu2, Yulin Ge 1
1The Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, NYU Grossman School of Medicine, New York, United States of America
2Department of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Presenting Author: Yulin Ge

Synopsis

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References

1. Ferrer-Gallardo, V. J., Esteban-Peñalba, T., Rodriguez-Oroz, M. C., Caballero-Gaudes, C., & Paz-Alonso, P. M. (2025). Thalamic nuclei volume changes associated with cognitive and motor manifestations of Parkinson's disease. NPJ Parkinsons Dis, 11(1), 279. doi:10.1038/s41531-025-01129-2 [doi]
2. Samii, A., Nutt, J. G., & Ransom, B. R. (2004). Parkinson's disease. Lancet, 363(9423), 1783-1793. doi:10.1016/s0140-6736(04)16305-8 [doi]
3. Lees, A. J., Hardy, J., & Revesz, T. (2009). Parkinson's disease. Lancet, 373(9680), 2055-2066. doi:10.1016/s0140-6736(09)60492-x [doi]
4. Bookheimer, S. Y., Salat, D. H., Terpstra, M., Ances, B. M., Barch, D. M., Buckner, R. L., . . . Yacoub, E. (2019). The Lifespan Human Connectome Project in Aging: An overview. Neuroimage, 185, 335-348. doi:10.1016/j.neuroimage.2018.10.009 [doi]
5. Harms, M. P., Somerville, L. H., Ances, B. M., Andersson, J., Barch, D. M., Bastiani, M., . . . Yacoub, E. (2018). Extending the Human Connectome Project across ages: Imaging protocols for the Lifespan Development and Aging projects. Neuroimage, 183, 972-984. doi:10.1016/j.neuroimage.2018.09.060 [doi]
6. Drori, E., Berman, S., & Mezer, A. A. (2022). Mapping microstructural gradients of the human striatum in normal aging and Parkinson's disease. Sci Adv, 8(28), eabm1971. doi:10.1126/sciadv.abm1971 [doi]

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http://echo.ismrm.org/p/ISMRM2026/362-06-003