Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
552-03-002 / 552-03-002 ISMRM Abstract

Glymphatic Dysfunction Assessed by DTI-ALPS Mediates FDG-PET Metabolic-Cognitive Coupling in Parkinson's Disease Subtypes

Primary: Neuro - Parkinson's Disease
Secondary: Diffusion - DWI/DTI/DKI
552-03-002 · Diffusion Methodologies and Clinical Applications · Wednesday, 13 May, 4:00 PM–5:36 PM · Power Pitch Theatre 2
552-03-002 · Diffusion Methodologies and Clinical Applications · Wednesday, 13 May, 4:00 PM–5:36 PM · Power Pitch Theatre 2
Keywords: Parkinson's Disease Cognitive impairment Multimodal imaging FDG-PET Diffusion Tensor Imaging (DTI)
Accepted
Wenli Zhang1, Guoyang Li1, Fengju Mao1, Hong Zhao1, Long Zhao1, Yutong Guo 2, Chang Sun2, Yang Yang3, Xiangcheng Wang1, Xiaoguang Luo1
1Shenzhen People's Hospital, ShenZhen, China
2Shanghai United Imaging Healthcare Co., Ltd, Shanghai, China
3Beijing United Imaging Healthcare Co., Ltd, Beijing, China
Presenting Author: Yutong Guo

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References

1. Kehagia AA, Barker RA, Robbins TW. Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease. Lancet Neurol. 2010 Dec;9(12):1200-1213. doi: 10.1016/S1474-4422(10)70212-X. [doi]
2. Nedergaard M, Goldman SA. Glymphatic failure as a final common pathway to dementia. Science. 2020 Oct 2;370(6512):50-56. doi: 10.1126/science.abb8739. [doi]
3. Chu M, Yue A, Yan S, Yu B, He Q, Chen Y, Hou J, Nan H, Ye H, Nie B, Rosa-Neto P, Qu M, Lu J, Wu L. Glymphatic activity in behavioral variant frontotemporal dementia: Link with vascular function and astrocytic activation. Alzheimers Dement. 2025 Aug;21(8):e70561. doi: 10.1002/alz.70561. [doi]
4. Jiang D, Liu L, Kong Y, Chen Z, Rosa-Neto P, Chen K, Ren L, Chu M, Wu L; Regional Glymphatic Abnormality in Behavioral Variant Frontotemporal Dementia. Ann Neurol. 2023 Sep;94(3):442-456. doi: 10.1002/ana.26710. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/552-03-002