Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
369-05-015 ISMRM Abstract

Initial Validation of 129Xe RBC oscillation phase mapping against DCE-MRI and blood flow modelling in patients with CTEPH

Primary: Contrast Mechanisms - Hyperpolarized MR (Gas)
Secondary: Body - Lung
369-05-015 · Hyperpolarized Gases · Monday, 11 May, 4:10 PM–5:05 PM · Digital Posters Row J
Keywords: Perfusion Hyperpolarized 129Xe MRI Functional lung imaging
Accepted
Jemima H Pilgrim-Morris 1,2, Behdad Shaarbaf Ebrahimi3, Evelyn Baldry1,2, Laura C Saunders1,2, Paul J Hughes1, Scarlett Strickland4, Roger Thompson1,4, Guilhem J Collier1,2, Neil J Stewart1,2, Jim Wild1,2
1POLARIS, Division of Clinical Medicine, School of Medicine & Population Health, The University of Sheffield, Sheffield, United Kingdom
2INSIGNEO Institute for In Silico Medicine, The University of Sheffield, Sheffield, United Kingdom
3Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand
4Sheffield Teaching Hospitals, Sheffield, United Kingdom
Presenting Author: Jemima H Pilgrim-Morris

Synopsis

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References

1. Bier EA, Robertson SH, Schrank GM, et al., A protocol for quantifying cardiogenic oscillations in dynamic (129) Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis. NMR Biomed, 2019. 32(1): p. e4029. doi:10.1002/nbm.4029 [doi]
2. Niedbalski PJ, Bier EA, Wang Z, et al., Mapping cardiopulmonary dynamics within the microvasculature of the lungs using dissolved 129Xe MRI. Journal of Applied Physiology, 2020. 129(2): p. 218-229. doi:10.1152/japplphysiol.00186.2020 [doi]
3. Lu J, Alenezi F, Bier E, et al. Optimized quantitative mapping of cardiopulmonary oscillations using hyperpolarized 129Xe gas exchange MRI: digital phantoms and clinical evaluation in CTEPH. Magn Reson Med. 2024;91:1541‐1555. doi:10.1002/mrm.29965 [doi]
4. Pilgrim-Morris JH, Collier GC, Takigawa M, et al. Mapping the amplitude and phase of dissolved 129Xe red blood cell signal oscillations with keyhole spectroscopic lung imaging. Mag Reson Med, 2025. 93(2): 584-596. doi:10.1002/mrm.30296 [doi]
5. Collier GJ, Smith LJ, Saunders LC,et al. Age, sex, and lung volume dependence of dissolved xenon-129 MRI gas exchange metrics. Magn Reson Med. 2024. 92(4):1471-1483. doi:10.1002/mrm.30133 [doi]
6. Norquay G, Collier GJ, Rao M, Stewart NJ, and Wild JM, 129Xe-Rb Spin-Exchange Optical Pumping with High Photon Efficiency. Physical Review Letters, 2018. 121(15): p. 153201. doi:10.1103/PhysRevLett.121.153201 [doi]
7. Tustison NJ, Cook PA, Holbrook AJ, et al. The ANTsX ecosystem for quantitative biological and medical imaging. Scientific Reports, 2021. 11(1):9068. doi:10.1038/s41598-021-87564-6 [doi]
8. Axel L. Methods using blood pool tracers. In: D Le Bihan, editor. Magnetic resonance perfusion and diffusion imaging. New York: Raven Press; 1995. p 205–211.
9. Schiwek M, Triphan SMF, Biederer J et al; COSYCONET study group. Quantification of pulmonary perfusion abnormalities using DCE-MRI in COPD: comparison with quantitative CT and pulmonary function. Eur Radiol. 2022 Mar;32(3):1879-1890. doi:10.1007/s00330-021-08229-6 [doi]
10. Ebrahimi BS, Tawhai MH, Kumar H, et al. A computational model of contributors to pulmonary hypertensive disease: impacts of whole lung and focal disease distributions. Pulm Circ, 2021. 11(4):20458940211056527. doi:10.1177/20458940211056527 [doi]
11. Ebrahimi BS, Khwaounjoo P, Chan H-F, et al. Patient-Specific Haemodynamic Modeling to Estimate the Extent of Microvascular Disease and Response to Pulmonary Endarterectomy in Chronic Thromboembolic Pulmonary Hypertension. Pulm Circ, 2025. 15(4):1-16. doi:10.1002/pul2.70176 [doi]
12. Heath D and Edwards JE. The pathology of hypertensive pulmonary vascular disease. Circulation, 1958. 18(4):533–547. doi:10.1161/01.cir.18.4.533 [doi]

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http://echo.ismrm.org/p/ISMRM2026/369-05-015