Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
465-05-007 ISMRM Abstract

Connectome-Based Characterization of the Sleep–Wake Regulatory Network in Narcolepsy Type 1

Primary: Diffusion - Tractography
Secondary: Neuro - Other Neurodegeneration
465-05-007 · Tractography Applications · Tuesday, 12 May, 4:00 PM–4:55 PM · Digital Posters Row F
Keywords: Brain Neurodegeneration Structural Connectivity Sleep disorders Microstructural alterations
Accepted
Francesca Punzetti 1, Lorenzo Motta1, Greta Venturi1, Fabio Pizza2,3, Giovanni Sighinolfi1,4, Francesco Biscarini3,4, Martina Gnazzo3,5, Giuseppe Plazzi3,5, Raffaele Lodi1,2, Caterina Tonon1,2
1Programma Neuroimmagini Funzionali e Molecolari, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
2Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy
3Clinica Neurologica, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
4IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
5Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio-Emilia, Italy
Presenting Author: Francesca Punzetti

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Bassetti, C. L. A., Adamantidis, A., Burdakov, D., Han, F., Gay, S., Kallweit, U., … Dauvilliers, Y. (2019). Narcolepsy — clinical spectrum, aetiopathophysiology, diagnosis and treatment. Nature Reviews Neurology, 15(9), 519–539. doi: 10.1038/s41582-019-0226-9 [doi]
2. Gool, J. K., Fronczek, R., Leemans, A., Kies, D. A., Lammers, G. J., & Van Der Werf, Y. D. (2019). Widespread white matter connectivity abnormalities in narcolepsy type 1: A diffusion tensor imaging study. NeuroImage: Clinical, 24, 101963. doi: 10.1016/j.nicl.2019.101963 [doi]
3. Zhang, H., Xu, L., Ai, Z., Wang, L., Wang, L., Li, L., … Wang, Z. (2024). The brain topological alterations in the structural connectome and correlations with clinical characteristics in type 1 narcolepsy. NeuroImage: Clinical, 44, 103697. doi: 10.1016/j.nicl.2024.103697 [doi]
4. Lu, F.-M., Dai, J., Couto, T. A., Liu, C.-H., Chen, H., Lu, S.-L., … Yuan, Z. (2017). Diffusion Tensor Imaging Tractography Reveals Disrupted White Matter Structural Connectivity Network in Healthy Adults with Insomnia Symptoms. Frontiers in Human Neuroscience, 11, 583. doi: 10.3389/fnhum.2017.00583 [doi]
5. Hovi, M., Roine, U., Autti, T., Heiskala, H., Roine, T., & Kirjavainen, T. (2024). Microstructural White Matter Abnormalities in Children and Adolescents With Narcolepsy Type 1. Pediatric Neurology, 153, 56–64. doi: 10.1016/j.pediatrneurol.2024.01.015 [doi]
6. Brun, G., Testud, B., Girard, O. M., Lehmann, P., De Rochefort, L., Besson, P., … Le Troter, A. (2022). Automatic segmentation of deep grey nuclei using a high‐resolution 7T magnetic resonance imaging atlas—Quantification of T1 values in healthy volunteers. European Journal of Neuroscience, 55(2), 438–460. doi: 10.1111/ejn.15575 [doi]
7. Edlow, B., & Kinney, H. (2023, July 18). Harvard Ascending Arousal Network Atlas – Version 2.0. Dryad. doi: 10.5061/DRYAD.ZW3R228D2 [doi]
8. Thannickal, T. C., Siegel, J. M., Nienhuis, R., & Moore, R. Y. (2003). Pattern of Hypocretin (Orexin) Soma and Axon Loss, and Gliosis, in Human Narcolepsy. Brain Pathology, 13(3), 340–351. doi: 10.1111/j.1750-3639.2003.tb00033.x [doi]
9. Moore, R. Y., Abrahamson, E. A., & Van Den Pol, A. (2001). The hypocretin neuron system: an arousal system in the human brain. Archives Italiennes De Biologie, 139(3), 195–205.
10. Li, S.-B., & De Lecea, L. (2020). The hypocretin (orexin) system: from a neural circuitry perspective. Neuropharmacology, 167, 107993. doi: 10.1016/j.neuropharm.2020.107993 [doi]
11. Motta, Venturi, et al. Iron-related susceptibility changes in brainstem arousal centres in adult narcolepsy type 1: insights from quantitative susceptibility mapping. Book of Abstracts ESMRMB 2025 Online 41st Annual Scientific Meeting 8–11 October 2025. (2025). Magnetic Resonance Materials in Physics, Biology and Medicine, s10334-025-01278–8. doi: 10.1007/s10334-025-01278-8 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/465-05-007