Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
430-04-003 ISMRM Abstract

Monitor metabolic changes in High-Altitude Acute Myocardial Injury using hyperpolarized ¹³C MRS

Primary: Preclinical Animal & in vitro MR - Probes & Targets
Secondary: Cardiovascular - Myocardium
430-04-003 · Cardiovascular and Body Imaging · Tuesday, 12 May, 4:00 PM–5:50 PM · Meeting Room 2.60
Keywords: Hyperpolarized MR (Non-Gas) Cardiac MRS 1-13C Pyruvate Energy metabolism High-altitude myocardial injury(HAMI)
Accepted
Xiyuan Zhong 1, Changwei He1, Minjie Zhu2, XiaoFang Yang3, Yunxi Lv4, Jinxia Guo4, Min Wu1,5
1Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China
2Department of Radiology and Biomedical Imaging, University Of California, San Francisco (UCSF), United States of America
3Department of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, West China Hospital of Sichuan University, Chengdu, China
4GE Healthcare, Beijing, China
5Sichuan Provincial Engineering Research Center of Intelligent Medical Imaging, West China Hospital, Sichuan University( Chengdu, China), Chengdu, China
Presenting Author: Xiyuan Zhong

Synopsis

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References

1. Zhao S, et al. Pretreatment with Notoginsenoside R1 attenuates high-altitude hypoxia-induced cardiac injury via activation of the ERK1/2-P90RSK-Bad signaling pathway in rats. Phytother Res. 2023 Oct;37(10):4522-4539. doi: 10.1002/ptr.7923. Epub 2023 Jun 14. PMID: 37313866. [doi] [pmid]
2. Li AL, et al. The role of mitochondria in myocardial damage caused by energy metabolism disorders: From mechanisms to therapeutics. Free Radic Biol Med. 2023 Nov 1;208:236-251. doi: 10.1016/j.freeradbiomed.2023.08.009. Epub 2023 Aug 9. PMID: 37567516. [doi] [pmid]
3. Burtscher M, et al. The risk of death to trekkers and hikers in the mountains. JAMA. 1995 Feb 8;273(6):460. doi: 10.1001/jama.1995.03520300030031. PMID: 7837363. [doi] [pmid]
4. Tremblay JC, Ainslie PN. Global and country-level estimates of human population at high altitude. Proc Natl Acad Sci U S A. 2021 May 4;118(18):e2102463118. doi: 10.1073/pnas.2102463118. PMID: 33903258; PMCID: PMC8106311. [doi] [pmid]
5. Damen SAJ, et al. Cardiac troponin complexes and fragments: potential targets for improved clinical performance. Crit Rev Clin Lab Sci. 2025 Aug;62(5):313-326. doi: 10.1080/10408363.2025.2484954. Epub 2025 Apr 12. PMID: 40219723. [doi] [pmid]
6. Luks AM, et al. Acute high-altitude sickness. Eur Respir Rev. 2017 Jan 31;26(143):160096. doi: 10.1183/16000617.0096-2016. PMID: 28143879; PMCID: PMC9488514. [doi] [pmid]
7. Jørgensen SH, et al. Hyperpolarized MRI - An Update and Future Perspectives. Semin Nucl Med. 2022 May;52(3):374-381. doi: 10.1053/j.semnuclmed.2021.09.001. Epub 2021 Nov 14. PMID: 34785033. [doi] [pmid]
8. Fuetterer M, et al. Hyperpolarized Metabolic and Parametric CMR Imaging of Longitudinal Metabolic-Structural Changes in Experimental Chronic Infarction. JACC Cardiovasc Imaging. 2022 Dec;15(12):2051-2064. doi: 10.1016/j.jcmg.2022.08.017. Epub 2022 Nov 16. PMID: 36481073. [doi] [pmid]

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http://echo.ismrm.org/p/ISMRM2026/430-04-003