Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
664-02-008 ISMRM Abstract

Development of a Perinatal Lamb Brain MRI Template and Atlas for Translational Neurodevelopmental Research

Primary: Analysis Methods - Image Registration and Alignment
Secondary: Preclinical Animal & in vitro MR - Large Animals, Nonhuman Primates
664-02-008 · Large Animals · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row E
Keywords: MRI atlases Whole Brain Segmentation Large animal model Template Fetal brain
Accepted
Nina Odgaard 1,2, Kelly Payette2, Christian T Stoeck3,4, Ahmed A Hassan5, Rajiv R Chaturvedi5, Michael Seed5, Monique C Haak6, Edgar T Jaeggi5, Miriam Weisskopf4, Walter Knirsch1, Andras Jakab2
1Department of Cardiology, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland
2Center for MR Research, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland
3Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland
4Center for Preclinical Development University of Zurich and University Hospital Zurich, Zurich, Switzerland
5Department of Paediatrics, Labatt Family Heart Centre, Division of Cardiology, The Hospital for Sick Children, Toronto, Canada
6Department of Obstetrics and Fetal Medicine, Leiden University Medical Center, Leiden, Netherlands
Presenting Author: Nina Odgaard

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Back SA, Riddle A, Dean J, Hohimer AR. The Instrumented Fetal Sheep as a Model of Cerebral White Matter Injury in the Premature Infant. Neurotherapeutics. 2012;9(2):359-370. doi:10.1007/s13311-012-0108-y [doi]
2. Schlabritz-Loutsevitch N, Carter AM. Rodent, Sheep, and Nonhuman Primates as Models for Human Pregnancy and Fetal Development. In: Hau J, Schapiro SJ, eds. Handbook of Laboratory Animal Science: Essential Principles and Practices. Fourth edition. CRC Press; 2021:545-560.
3. Reuter MS, Sokolowski DJ, Javier Diaz-Mejia J, et al. Decreased left heart flow in fetal lambs causes left heart hypoplasia and pro-fibrotic tissue remodeling. Communications Biology. 2023;6(1). doi:10.1038/s42003-023-05132-2 [doi]
4. Fedorov A, Beichel R, Kalpathy-Cramer J, et al. 3D Slicer as an image computing platform for the Quantitative Imaging Network. Magnetic Resonance Imaging. 2012;30(9):1323-1341. doi:10.1016/j.mri.2012.05.001 [doi]
5. Yushkevich PA, Piven J, Hazlett HC, et al. User-guided 3D active contour segmentation of anatomical structures: Significantly improved efficiency and reliability. NeuroImage. 2006;31(3):1116-1128. doi:10.1016/j.neuroimage.2006.01.015 [doi]
6. Avants BB, Tustison NJ, Song G, Cook PA, Klein A, Gee JC. A reproducible evaluation of ANTs similarity metric performance in brain image registration. NeuroImage. 2011;54(3):2033-2044. doi:10.1016/j.neuroimage.2010.09.025 [doi]
7. Payette K, Li HB, De Dumast P, et al. Fetal brain tissue annotation and segmentation challenge results. Medical Image Analysis. 2023;88:102833. doi:10.1016/j.media.2023.102833 [doi]
8. 1. Johnson JI, Sudheimer KD, Davis KK, Kerndt GM, Winn BM. The Sheep Brain Atlas at Michigan State University. Michigan University Brain Biodiversity Bank. July 18, 2025. Accessed July 18, 2025. https://brains.anatomy.msu.edu/brains/sheep/index.html

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/664-02-008