364-02-010 ISMRM Abstract

Radiogenomic profiling reveals molecular heterogeneity in H3 K27-altered diffuse midline glioma

Primary: Neuro - Tumors

Secondary: Analysis Methods - Radiomics

364-02-010 · Innovations in Brain Tumor Imaging: Quantitative MRI, Radiogenomics, and Deep-Learning Approaches · Monday, 11 May, 9:15 AM–10:10 AM · Digital Posters Row E

Keywords: Radiogenomics H3 K27-altered diffuse midline glioma

Accepted

Qianqian Zheng¹, Xiaorui Su¹, Yujiao Deng¹, Xibiao Yang¹, Shuang Tang¹, Qiang Yue¹

¹West China Hospital of Sichuan University, Chendu, China

Presenting Author: Qiuxing Chen

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References

1. Louis DN, Perry A, Wesseling P, et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol. Aug 2 2021;23(8):1231-1251. doi:10.1093/neuonc/noab106 [doi]

2. Weller M, Wen PY, Chang SM, et al. Glioma. Nat Rev Dis Primers. May 9 2024;10(1):33. doi:10.1038/s41572-024-00516-y [doi]

3. Solomon DA, Wood MD, Tihan T, et al. Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations. Brain Pathol. Sep 2016;26(5):569-80. doi:10.1111/bpa.12336 [doi]

4. Deng Y, Su X, Yang Y, Gong J, Chen N, Yue Q. Histopathological grades as prognostic factors of H3 K27-altered diffuse midline glioma and their prediction using multiparametric MR imaging. Neuroradiology. Jun 6 2025;doi:10.1007/s00234-025-03660-8 [doi]

5. Ma J, Setton J, Morris L, et al. Genomic analysis of exceptional responders to radiotherapy reveals somatic mutations in ATM. Oncotarget. Feb 7 2017;8(6):10312-10323. doi:10.18632/oncotarget.14400 [doi]

6. Fusco MJ, West HJ, Walko CM. Tumor Mutation Burden and Cancer Treatment. JAMA Oncol. Feb 1 2021;7(2):316. doi:10.1001/jamaoncol.2020.6371 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/364-02-010