Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
352-03-005 / 352-03-005 ISMRM Abstract

Delayed neurovascular–CSF Coupling in Adolescents with Subclinical Depression

Primary: Neuro - Neurofluids
Secondary: Brain Function and fMRI - fMRI & Neuromodulation
352-03-005 · Neurofluid Dynamics in Sleep and Disease · Monday, 11 May, 4:10 PM–5:46 PM · Power Pitch Theatre 2
352-03-005 · Neurofluid Dynamics in Sleep and Disease · Monday, 11 May, 4:10 PM–5:46 PM · Power Pitch Theatre 2
Keywords: Cerebrospinal fluid Adolescent subclinical depression Low-frequency BOLD Dynamic correlation Neurovascular-glymphatic coupling
Accepted
Zhongli Lan 1, JieFeng Gan2, Chengfeng Zhang2, Weiyin Vivian Liu3, Jun Chen2,4
1The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China
2Guangdong Provincial Hospital of Chinese Medicine, Zhuhai, China
3GE Healthcare, MR Research China, Beijing, China
4Department of Radiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
Presenting Author: Zhongli Lan

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References

1. Fultz, N. E., Bonmassar, G., Setsompop, K., Stickgold, R. A., Rosen, B. R., Polimeni, J. R., & Lewis, L. D. (2019). Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep. Science, 366(6465), 628–631. https://doi.org/10.1126/science.aax5440 [doi]
2. Han, F., Chen, J., Belkin-Rosen, A., Gu, Y., Luo, L., et al. (2021). Reduced coupling between cerebrospinal fluid flow and global brain activity is linked to Alzheimer disease–related pathology. PLOS Biology, 19(6), e3001233. https://doi.org/10.1371/journal.pbio.3001233 [doi]
3. Zhang, Y., Wang, L., & Liu, H. (2024). Reduced coupling between global signal and cerebrospinal fluid inflow in patients with depressive disorder: A resting-state fMRI study. Journal of Affective Disorders, 354, 136–142. https://doi.org/10.1016/j.jad.2024.03.023 [doi]
4. Roefs, E. C. A., van der Toorn, A., & van Osch, M. J. P. (2024). BOLD–CSF dynamics assessed using real-time phase-contrast CSF flow interleaved with cortical BOLD MRI. Fluids and Barriers of the CNS, 21(1), 58. https://doi.org/10.1186/s12987-024-00607-8 [doi]
5. Chen, S., Xu, Z., & Qiu, Y. (2025). Glymphatic dysfunction associated with cortisol dysregulation in major depressive disorder. Translational Psychiatry, 15, 265. https://doi.org/10.1038/s41398-025-03486-1 [doi]
6. Cheng, H., Zhang, Y., & Han, F. (2025). Temporal fluctuation in lateral ventricle volume and its coupling to global BOLD signal. Scientific Reports, 15, 8428. https://doi.org/10.1038/s41598-025-15842-8 [doi]
7. Pawlak, M. K., Cribben, I., Waschbusch, K., & Goldstein, A. L. (2022). Resting-state functional connectivity as a marker of subclinical depression and anxiety in adolescent females. Scientific Reports, 12, 21786. https://doi.org/10.1038/s41598-022-25805-y [doi]
8. Owashi, K. P., et al. (2024). Phase-contrast MRI analysis of cerebral blood and CSF flow to evaluate blood–CSF dynamics interactions. Fluids and Barriers of the CNS, 21(1), 32. https://doi.org/10.1186/s12987-024-00578-w [doi]

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http://echo.ismrm.org/p/ISMRM2026/352-03-005