Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
552-01-012 / 552-01-012 ISMRM Abstract

Age-related Changes in Neurometabolite Levels during Early Infancy: Using HBCD MRS Data Release 1.0

Primary: Pediatrics - Normal Development
Secondary: Contrast Mechanisms - Spectroscopy
552-01-012 · Novel Approaches to Spectroscopy · Wednesday, 13 May, 8:20 AM–9:56 AM · Power Pitch Theatre 2
552-01-012 · Novel Approaches to Spectroscopy · Wednesday, 13 May, 8:20 AM–9:56 AM · Power Pitch Theatre 2
Keywords: MR spectroscopy Brain Development Metabolite Quantification
Accepted
Saipavitra Murali-Manohar1, Helge J Zöllner1, Christopher W Davies-Jenkins1, Aaron T Gudmundson1,2, Steve C Hui3,4,5, Yulu Song1, Gizeaddis Simegn1, Zahra Shams1, Abdelrahman Gad1, Borjan Gagoski6,7, M. Dylan Tisdall8, Muhammad G Saleh8,9, Ralph Noeske10, William T Clarke11, Timothy J Hendrickson12,13,14, Erik G Lee12,13,14, Heather E Volk15, Georg Oeltzschner1, Jessica Wisnowski 16,17, Richard AE Edden1
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United States of America
2The Malone Center for Engineering in Healthcare, Johns Hopkins University, Baltimore, United States of America
3Developing Brain Institute, Children's National Hospital, Washington DC, United States of America
4Department of Radiology, George Washington University, Washington, United States of America
5Department of Pediatrics, George Washington University, Washington, United States of America
6Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, United States of America
7Department of Radiology, Harvard Medical School, Boston, United States of America
8Department of Radiology, University of Pennsylvania, Philadelphia, United States of America
9Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, United States of America
10GE Healthcare, Munich, Germany
11Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
12Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, United States of America
13Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, United States of America
14Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, United States of America
15Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America
16Department of Radiology and Pediatrics, Children's Hospital Los Angeles, Los Angeles, United States of America
17University of Southern California, Los Angeles, United States of America
Presenting Author: Jessica Wisnowski

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References

1. Dean DC, Tisdall MD, Wisnowski JL, et al. Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol. Developmental Cognitive Neuroscience. 2024;70:101452. doi:10.1016/j.dcn.2024.101452 [doi]
2. Blüml S, Wisnowski JL, Nelson MD Jr, et al. Metabolic Maturation of the Human Brain From Birth Through Adolescence: Insights From In Vivo Magnetic Resonance Spectroscopy. Cerebral Cortex. 2013;23(12):2944-2955. doi:10.1093/cercor/bhs283 [doi]
3. Hui SCN, Murali-Manohar S, Zöllner HJ, et al. Integrated Short-TE and Hadamard-edited Multi-Sequence (ISTHMUS) for advanced MRS. Journal of Neuroscience Methods. 2024;409:110206. doi:10.1016/j.jneumeth.2024.110206 [doi]
4. HBCD Consortium. (2025) HBCD Data Release Docs (1.0.0). doi:10.5281/zenodo.17317140 [doi]
5. Zöllner HJ, Davies-Jenkins CW, Lee EG, et al. Continuous Automated Analysis Workflow for MRS Studies. J Med Syst. 2023;47(1):69. doi:10.1007/s10916-023-01969-6 [doi]
6. Oeltzschner G, Zöllner HJ, Hui SCN, et al. Osprey: Open-source processing, reconstruction & estimation of magnetic resonance spectroscopy data. Journal of Neuroscience Methods. 2020;343:108827. doi:10.1016/j.jneumeth.2020.108827 [doi]
7. Kreis R, Ernst T, Ross BD. Development of the human brain: In vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy. Magnetic Resonance in Med. 1993;30(4):424-437. doi:10.1002/mrm.1910300405 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/552-01-012