369-05-009 ISMRM Abstract

Water Stable Multivariate Metal-Organic Framework for Enhanced Hyperpolarized Xenon MRI in Living Cells

Primary: Contrast Mechanisms - Hyperpolarized MR (Gas)

Secondary: Contrast Mechanisms - CEST / APT / NOE

369-05-009 · Hyperpolarized Gases · Monday, 11 May, 4:10 PM–5:05 PM · Digital Posters Row J

Keywords: MTV-MOF Hyper-CEST MRI Cellular Imaging Signal enhancement

Accepted

Zhen Wang^1,2, Qingbin Zeng^1,2, Qianni Guo^1,2, Xinxin Yang ^1,2, Xin Zhou^1,2,3

¹Innovation Academy for Precision Measurement Science and Technology,CAS, Wuhan, China

²University of Chinese Academy of Sciences, Beijing, China

³School of Biomedical Engineering, Hainan University, Haikou, China

Presenting Author: Xinxin Yang

Synopsis

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References

1. Wang Y, Dmochowski I. An expanded palette of xenon-129 NMR biosensors. Acc Chem Res, 2016, 49(10): 2179-2187. DOI: 10.1021/acs.accounts.6b00309. [doi]

2. Zeng Q, Bie B, Guo Q, et al. Hyperpolarized Xe NMR signal advancement by metal-organic framework entrapment in aqueous solution. Proc Natl Acad Sci U S A, 2020, 117(30): 17558–17563. DOI:10.1073/pnas.2004121117. [doi]

3. Deng H, Doonan C J, Furukawa H, et al. Multiple functional groups of varying ratios in metal-organic frameworks. Science, 2010, 327: 846-850. DOI: 10.1126/science.1181761. [doi]

4. Ahnfeldt T, Guillou N, Gunzelmann D, et al. [Al4(OH)2(OCH3)4(H2N-bdc)3]⋅x H2O: A 12-connected porous metal–organic framework with an unprecedented aluminum-containing brick. Angew Chem Int Ed, 2010, 48(28): 5163-5166. DOI: 10.1002/anie.200901409. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/369-05-009