Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
551-03-016 / 551-03-016 ISMRM Abstract

How does brain iron distribution differ in "SuperAgers” vs. normal aging?

Primary: Neuro - Aging
Secondary: Contrast Mechanisms - Susceptibility/QSM
551-03-016 · Advanced MRI Biomarkers of Brain Aging, Vascular Health, and Alzheimer’s Disease · Wednesday, 13 May, 4:00 PM–5:36 PM · Power Pitch Theatre 1
551-03-016 · Advanced MRI Biomarkers of Brain Aging, Vascular Health, and Alzheimer’s Disease · Wednesday, 13 May, 4:00 PM–5:36 PM · Power Pitch Theatre 1
Keywords: Neurodegeneration Aging Iron Overload Quantitative Susceptibility Mapping (QSM) SuperAgers
Accepted
Fábio Otsuka 1, Bruno F Pastorello1, Giovanni G Cerri1, Paulo A Lotufo2,3, Isabela Benseñor2,3, Claudia K Suemoto3, Alessandra C Goulart2,4, Claudia C Leite1, Maria Garcia Otaduy1
1LIM44-Instituto de Radiologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
2Center for Clinical and Epidemiological Research, Hospital Universitario da Universidade de São Paulo, São Paulo, Brazil
3Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
4Department of Epidemiology, School of Public Health, Universidade de São Paulo, São Paulo, Brazil
Presenting Author: Fábio Otsuka

Synopsis

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References

1. Nassif C, et al. Integrity of Neuronal Size in the Entorhinal Cortex Is a Biological Substrate of Exceptional Cognitive Aging. J Neurosci. 2022 Nov 9;42(45):8587-8594. doi: 10.1523/JNEUROSCI.0679-22.2022. PMID: 36180225. [doi] [pmid]
2. Rao SS, et al. Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology. Neurotherapeutics. 2021 Apr;18(2):1081-1094. doi: 10.1007/s13311-020-00972-w. [doi]
3. Passos VMA et al. Methods of cognitive function investigation in the Longitudinal Study on Adult Health (ELSA-Brasil). Sao Paulo Medical Journal, v. 132, n. 3, p. 170–177, 2014.
4. 4. He C, et al. Quantitative susceptibility atlas construction in Montreal Neurological Institute space: towards histological-consistent iron-rich deep brain nucleus subregion identification. Brain Struct Funct. 2023 Jun;228(5):1045-1067. doi: 10.1007/s00429-022-02547-1. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/551-03-016