Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
563-06-012 ISMRM Abstract

2-Hydroxyglutarate-edited Deep Learning Complex Frequency and Phase Correction

Primary: Contrast Mechanisms - Spectroscopy
Secondary: Neuro - Tumors
563-06-012 · From Molecular Signatures to Surgical Guidance: Cutting-Edge MRI in Brain Tumor Care · Wednesday, 13 May, 4:55 PM–5:50 PM · Digital Posters Row D
Keywords: In vivo proton magnetic resonance spectroscopy Neuro-Oncology Edited magnetic resonance spectroscopy 2-hydroxyglutarate Frequency and phase correction
Accepted
Hanna Bugler 1,2,3,4, Gerd Melkus5,6,7, Thanh Nguyen5,6,8, Roberto Souza2,9, Ashley D Harris 2,10,11
1University of Calgary, Calgary, Canada
2Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
3Biomedical Engineering, University of Calgary, Calgary, Canada
4Alberta Children's Hospital Research Insitute, Calgary, Canada
5Radiology, Radiation Oncology and Medical Physics, The University of Ottawa, Ottawa, Canada
6Ottawa Hospital Research Institute (OHRI), Ottawa, Canada
7Physics, Carleton University, Ottawa, Canada
8Faculty of Medicine, The University of Ottawa, Ottawa, Canada
9Electrical and Software Engineering, University of Calgary, Calgary, Canada
10Department of Radiology, University of Calgary, Calgary, Canada
11Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada
Presenting Author: Hanna Bugler

Synopsis

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References

1. Choi C, Ganji SK, DeBerardinis RJ, et al. 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas. Nat. Med. 2012; 18:624-629. doi: 10.1038/nm.2682. [doi]
2. Andronesi OC, Rapalino O, Gerstner E, et al. Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutatrate. J Clin Invest. 2013; 123(9):3659-63. doi: 10.1172/JCI67229. [doi]
3. Brun-Vergara ML, Melkus G, Chakraborty S, et al. Diagnostic Accuracy of 1H-MRS Using PRESS and MEGA-PRESS Techniques in the Preoperative Grading of Patients with Gliomas. J Magn Reson Imaging. 2025; 61(6):2480-2488. doi: 10.1002/jmri.29690. [doi]
4. Bugler H, Berto R, Souza R, Harris AD. Frequency and phase correction of GABA-edited magnetic resonance spectroscopy using complex-valued convolution neural networks. Magn Reson Imag. 2024; 111:186-195. doi:10.1016/j.mri.2024.05.008 [doi]
5. Simpson R, Devenyi GA, Jezzard P, Hennessy TJ, Near J. Advanced processing and simulation of MRS data using the FID appliance (FID-A)—An open source, MATLAB-based toolkit. Magn Reson Med. 2017;77(1):23-33. doi: 10.1002/mrm.26091. [doi]
6. Branzoli F, Di Stefano AL, Capelle L, et al.Highly specific determination of IDH status using edited in vivo magnetic resonance spectroscopy. 2018; 20(7):907-916. doi: 10.1093/neuonc/nox214. [doi]
7. Di Stefano AL, Nichelli L, Berzero G, et al. In Vivo 2-Hydroxyglutarate Monitoring with Edited MR Spectroscopy for the Follow-up of IDH-Mutant Diffuse Gliomas: The IDASPE Prospective Study. Neurology. 2023; 100(1):e94-e106. Doi: 10.1212/WNL.0000000000201137. [doi]
8. ranzoli F, Deelchand DK, Sanson M, et al. In vivo 1H MRS detection of cystathionine in human brain tumors. Magn Reson Med. 2019; 82(4): 1259-1265. doi: 10.1002/mrm.27810. [doi]
9. Choi C, Ganji SK, Madan A, et al. In vivo detection of citrate in brain tumors by 1H magnetic resonance spectroscopy at 3T. Magn Reson Med. 2013; 72(2):316-323. doi: 10.1002/mrm.24946. [doi]
10. Nguyen TB, Melkus G, Taccone M, et al. Preoperative Determination of Isocitrate Dehydrogenase Mutation in Gliomas Using Spectral Editing MRS: A Prospective Study. J Magn Reson Imaging. 2021; 53:416-426. doi: 10.1002/jmri/27366. [doi]
11. Bugler H, Shamaei A, Souza R, Harris AD. SMART MRS: A Simulated MEGA-PRESS Artifacts Toolbox for GABA-edited MRS. Magn Reson Med. 2025;94(5):1826-1839. doi: 10.1002/mrm.30597. [doi]
12. Wilson M, Andronesi O, Barker PB, et al. Methodological consensus on clinical proton MRS of the brain: Review and recommendations. Magn Reson Med. 2019; 82(2):527-550. doi: 10.1002/mrm.27742. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/563-06-012