Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
363-01-015 ISMRM Abstract

When Axons Falter and Myelin Fades: In Vivo Myelin Fraction Mapping Uncovers Neurovascular Thresholds in Brain Aging

Primary: Neuro - White Matter
Secondary: Neuro - Aging
363-01-015 · Neurological Application of Advanced Diffusion and Quantitative MRI · Monday, 11 May, 8:20 AM–9:15 AM · Digital Posters Row D
Keywords: Magnetization transfer White Matter Hypointensities Cerebral small vessel disease Demyelination White Matter Integrity
Accepted
Pavani K1, Niraj K Gupta 1, Vivek Tiwari1
1Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Berhampur, Odisha, India
Presenting Author: Niraj K Gupta

Synopsis

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References

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2. van der Weijden CWJ, Biondetti E, Gutmann IW, Dijkstra H, McKerchar R, de Paula Faria D, de Vries EFJ, Meilof JF, Dierckx RAJO, Prevost VH, Rauscher A. Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status. Brain. 2023 Apr 19;146(4):1243-1266. doi: 10.1093/brain/awac436. PMID: 36408715; PMCID: PMC10115240. [doi] [pmid]
3. Liu Z, Pardini M, Yaldizli Ö, Sethi V, Muhlert N, Wheeler-Kingshott CA, Samson RS, Miller DH, Chard DT. Magnetization transfer ratio measures in normal-appearing white matter show periventricular gradient abnormalities in multiple sclerosis. Brain. 2015 May;138(Pt 5):1239-46. doi: 10.1093/brain/awv065. Epub 2015 Mar 29. PMID: 25823475; PMCID: PMC5963416. [doi] [pmid]
4. Fischl B. FreeSurfer. Neuroimage. 2012 Aug 15;62(2):774-81. doi: 10.1016/j.neuroimage.2012.01.021. Epub 2012 Jan 10. PMID: 22248573; PMCID: PMC3685476. [doi] [pmid]
5. Gupta NK, Yadav N, Tiwari V. Brain aging and cognitive decline accelerate beyond a threshold of periventricular white matter hyperintensity. Cerebral Cortex. 2025. doi: 10.1093/cercor/bhaf302 [doi]
6. Yadav N, Gupta NK, Thakar D, Tiwari V. Magnitude and kinetics of a set of neuroanatomic volume and thickness together with white matter hyperintensity is definitive of cognitive status and brain age. Transl Psychiatry. 2024 Sep 27;14(1):389. doi: 10.1038/s41398-024-03097-2. PMID: 39333492; PMCID: PMC11437080. [doi] [pmid]

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http://echo.ismrm.org/p/ISMRM2026/363-01-015