464-02-005 ISMRM Abstract

Framework for Interpreting Low b-value Diffusion Tensor Imaging by Inferring Flow-velocity Vector Fields in Oscillatory Flow

Primary: Neuro - Neurofluids

Secondary: Diffusion - Diffusion Modeling

464-02-005 · Validating Diffusion MRI: Reproducibility, Simulations, and Phantoms · Tuesday, 12 May, 9:15 AM–10:10 AM · Digital Posters Row E

Keywords: Neurofluids Velocity & Flow Diffusion Tensor Imaging Physics-informed machine learning Cerebrospinal fluid flow

Accepted

Yoshitaka Bito ^1,2, Hiroyuki Kameda^2,3,4, Tomohiro Otani⁵, Noriyuki Fujima^1,2,4, Naoya Kinota^1,2,4, Daisuke Kato^1,4, Takaaki Fujii^1,4, Kinya Ishizaka⁶, Kenji Hirata^1,2,7, Kohsuke Kudo^1,2,4

¹Department of Diagnostic Imaging, Graduate School of Medicine, Hokkaido University, Sappro, Japan

²Global Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sappro, Japan

³Department of Radiology, Faculty of Dental Medicine, Hokkaido University, Sappro, Japan

⁴Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sappro, Japan

⁵Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, The University of Osaka, Suita, Japan

⁶Department of Radiological Technology, Hokkaido University Hospital, Sappro, Japan

⁷Department of Nuclear Medicine, Hokkaido University Hospital, Sappro, Japan

Presenting Author: Yoshitaka Bito

Synopsis

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References

1. Harrison IF, Siow B, Akilo AB, Evans PG, Ismail O, Ohene Y, Nahavandi P, Thomas DL, Lythgoe MF, Wells JA. Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI. Elife 2018;7:e34028. https://doi.org/10.7554/elife.34028. [doi]

2. Bito Y, Harada K, Ochi H, Kudo K. Low b-value diffusion tensor imaging for measuring pseudorandom flow of cerebrospinal fluid. Magn Reson Med 2021;86(3):1369-1382. https://doi.org/10.1002/mrm.28806. [doi]

3. Wright AM, Wu Y-C, Feng L, Wen Q. Diffusion magnetic resonance imaging of cerebrospinal fluid dynamics: Current techniques and future advancements. NMR in Biomedicine 2024;e5162. https://doi.org/10.1002/nbm.5162. [doi]

4. Bito Y, Ochi H, Shirase R, Yokohama W, Harada K, Kudo K. Low b-value diffusion tensor imaging to analyze the dynamics of cerebrospinal fluid: resolving intravoxel pseudorandom motion into ordered and disordered motions. Magn Reson Med Sci 2025;24(1):46-57. https://doi.org/10.2463/mrms.mp.2023-0081. [doi]

5. Otani T, Bito Y, Yamada S, Watanabe Y, Wada S. A theoretical interpretation of diffusion weighted and intravoxel incoherent motion imaging for cerebrospinal fluid flow. Magn Reson Med. 2025 Sep 4. https://doi.org/10.1002/mrm.70062. [doi]

6. Bito Y, Kameda H, Fujima N, Kinota N, Kato D, Fujii T, Ochi H, Ishizaka K, Hirata K, Kudo K. Formulation and simulation of low b-value DTI of pseudorandom flow in CSF. ISMRM 2025;#451.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/464-02-005