302-02-001 / 271-01-008 ISMRM Abstract

Functional lung MRI during tachypnea detects changes in regional ventilation after dual bronchodilator treatment in COPD

Primary: Body - Lung

Secondary: Analysis Methods - Data Processing

302-02-001 · Take a Breath: Chest, Thoracic, and Pulmonary MRI · Monday, 11 May, 8:20 AM–10:10 AM · Hall 1B

271-01-008 · ISMRM AMPC Selected Posters · Sunday, 10 May, 7:00 AM–2:00 PM · Traditional Posters

Keywords: Treatment Response Chronic obstructive pulmonary disease Lung MRI Functional lung imaging

Accepted

Robin A Müller ^1,2, Andreas Voskrebenzev^3,4, Filip Klimeš^2,3,5, Marius Klein^3,6, Frank Wacker^6,7, Jens Vogel-Claussen^4,6,8, Jens M Hohlfeld^1,2,9

¹Hannover Medical School, Hannover, Germany

²German Center for Lung Research (DZL), Munich, Germany

³Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany

⁴Biomedical Research in Endstage and Obstructive Lung Disease, German Center for Lung Research (DZL), Munich, Germany

⁵Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

⁶Member of the German Centre for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease, Hannover, Germany

⁷Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany

⁸Department of Radiology, Charité – Universitätsmedizin Berlin, Berlin, Germany

⁹Fraunhofer Institute of Toxicology and Experimental Medicine ITEM, Hannover, Germany

Presenting Author: Robin A Müller

Synopsis

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References

1. Hohlfeld JM, Vogel-Claussen J, Biller H, et al. Effect of lung deflation with indacaterol plus glycopyrronium on ventricular filling in patients with hyperinflation and COPD (CLAIM): a double-blind, randomised, crossover, placebo-controlled, single-centre trial. The Lancet Respiratory Medicine. 2018;6(5):368-378. doi:10.1016/S2213-2600(18)30054-7 [doi]

2. Cooper CB, Calligaro GL, Quinn MM, et al. Determinants of dynamic hyperinflation during metronome-paced tachypnea in COPD and normal subjects. Respiratory Physiology and Neurobiology. 2014;190(1):76-80. doi:10.1016/j.resp.2013.08.002 [doi]

3. Voskrebenzev A, Gutberlet M, Klimeš F, et al. Feasibility of quantitative regional ventilation and perfusion mapping with phase-resolved functional lung (PREFUL) MRI in healthy volunteers and COPD, CTEPH, and CF patients. Magnetic Resonance in Medicine. 2018;79(4):2306-2314. doi:10.1002/mrm.26893 [doi]

4. Müller RA, Klimeš F, Voskrebenzev A, et al. Phase-Resolved Functional Lung MRI Evaluation of Dynamic Hyperinflation Induced by Metronome-Paced Tachypnea in Patients with Chronic Obstructive Pulmonary Disease. COPD: Journal of Chronic Obstructive Pulmonary Disease. 2025;22(1). doi:10.1080/15412555.2025.2502671 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/302-02-001