Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
468-02-001 ISMRM Abstract

Iron Homeostasis Imbalance and Cognitive Dysfunction in Type 2 Diabetes: Insights from Quantitative Susceptibility Mapping

Primary: Neuro - Other Neurodegeneration
Secondary: Neuro - Dementia
468-02-001 · Type 2 Diabetes · Tuesday, 12 May, 9:15 AM–10:10 AM · Digital Posters Row I
Keywords: Type 2 diabetes mellitus Quantitative Susceptibility Mapping (QSM) Cognitive Dysfunction Iron deposition
Accepted
Zhenyu Cheng 1, Meng Li2, Qihao Zhang3,4,5, Jiaxiang Xin6, Jing Li7, Nan Zhang8, Yiwen Chen8, Pengcheng Liang8, Changhu Liang9, Lingfei Guo9
1Binzhou Medical University, Yantai City, Shandong Province, China
2Jena University Hospital, Jena, Germany
3Weill Cornell Medical College, New York, United States of America
4Radiology, Weill Cornell Medicine, New York, United States of America
5Department of Radiology, Weill Cornell Medicine, New York, United States of America
6MR Research Collaboration, Shanghai, China
7Beijing Tsinghua Changgung Hospital, Beijing, China
8Department of Radiograpy, Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong Provincial Hospital), Jinan, China
9Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong Provincial Hospital), Jinan, China
Presenting Author: Zhenyu Cheng

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References

1. Burillo, J.; Marqués, P.; Jiménez, B.; González-Blanco, C.; Benito, M.; Guillén, C. Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease. Cells 2021, 10 (5), 1236. https://doi.org/10.3390/cells10051236. [doi]
2. Li, J.; Zhang, Q.; Che, Y.; Zhang, N.; Guo, L. Iron Deposition Characteristics of Deep Gray Matter in Elderly Individuals in the Community Revealed by Quantitative Susceptibility Mapping and Multiple Factor Analysis. Front. Aging Neurosci. 2021, 13, 611891. https://doi.org/10.3389/fnagi.2021.611891. [doi]
3. Blasco, G.; Puig, J.; Daunis-I-Estadella, J.; Molina, X.; Xifra, G.; Fernández-Aranda, F.; Pedraza, S.; Ricart, W.; Portero-Otín, M.; Fernández-Real, J. M. Brain Iron Overload, Insulin Resistance, and Cognitive Performance in Obese Subjects: A Preliminary MRI Case-Control Study. Diabetes Care 2014, 37 (11), 3076–3083. https://doi.org/10.2337/dc14-0664. [doi]
4. Apostolakis, S.; Kypraiou, A.-M. Iron in Neurodegenerative Disorders: Being in the Wrong Place at the Wrong Time? Rev Neurosci 2017, 28 (8), 893–911. https://doi.org/10.1515/revneuro-2017-0020. [doi]
5. Galaris, D.; Barbouti, A.; Pantopoulos, K. Iron Homeostasis and Oxidative Stress: An Intimate Relationship. Biochim Biophys Acta Mol Cell Res 2019, 1866 (12), 118535. https://doi.org/10.1016/j.bbamcr.2019.118535. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/468-02-001