652-02-006 / 652-02-006 ISMRM Abstract

Respiratory and Cardiac Influences on Brain ADC: A Directional and Regional Analysis Using Dynamic DWI

Primary: Neuro - Neurofluids

Secondary: Diffusion - Diffusion Modeling

652-02-006 · Heart and Brain Interactions · Thursday, 14 May, 1:40 PM–3:16 PM · Power Pitch Theatre 2

Keywords: Neurofluid dynamics Dynamic diffusion-weighted imaging Cerebrospinal fluid (CSF) PHYSIOLOGICAL MODULATION RESPIRATION AND CARDIAC PULSATION

Accepted

João B de Oliveira ¹, Inês Esteves², Patricia Figueiredo², Andre M Paschoal³

¹Gleb Wataghin Institute of Physics, University of Campinas, Campinas, Brazil

²Institute for Systems and Robotics – Lisboa and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal

³University of Campinas, Campinas, Brazil

Presenting Author: João B de Oliveira

Synopsis

Motivation:

Goals:

Approach:

Results:

Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

References

1. Rasmussen MK, Mestre H, Nedergaard M. Fluid transport in the brain. Physiological Reviews. 2022 Apr;102(2):1025–151. doi:10.1152/physrev.00031.2020 [doi]

2. Fultz NE, Bonmassar G, Setsompop K, Stickgold RA, Rosen BR, Polimeni JR, et al. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep. Science. 2019 Nov 1;366(6465):628–31. doi:10.1126/science.aax5440. [doi]

3. Han G, Jiao B, Zhang Y, Wang Z, Liang C, Li Y, et al. Arterial pulsation dependence of perivascular cerebrospinal fluid flow measured by dynamic diffusion tensor imaging in the human brain. Neuroimage. 2024 Aug 15;297:120653. doi:10.1016/j.neuroimage.2024.120653 [doi]

4. Mestre H, Tithof J, Du T, Song W, Peng W, Sweeney AM, et al. Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension. Nat Commun. 2018 Nov 19;9:4878. doi:10.1038/s41467-018-07318-3 [doi]

5. Hirschler L, Runderkamp BA, Decker A, van Harten TW, Scheyhing P, Ehses P, et al. Region-specific drivers of CSF mobility measured with MRI in humans. Nat Neurosci. 2025 Oct 14;1–10. doi:10.1038/s41593-025-02073-3 [doi]

6. ISMRM 2025 [Internet]. [cited 2025 October 27]. Available from: https://submissions.mirasmart.com/ISMRM2025/Itinerary/ConferenceMatrixEventDetail.aspx?ses=O-69

7. Wen Q, Tong Y, Zhou X, Dzemidzic M, Ho CY, Wu YC. Assessing pulsatile waveforms of paravascular cerebrospinal fluid dynamics within the glymphatic pathways using dynamic diffusion-weighted imaging (dDWI). Neuroimage. 2022 Oct 15;260:119464. doi:10.1016/j.neuroimage.2022.119464 [doi]

8. Picchioni D, Özbay PS, Mandelkow H, de Zwart JA, Wang Y, van Gelderen P, et al. Autonomic arousals contribute to brain fluid pulsations during sleep. NeuroImage. 2022 Apr 1;249:118888. doi:10.1016/j.neuroimage.2022.118888 [doi]

9. Hoshi RA, Pastre CM, Vanderlei LCM, Godoy MF. Poincaré plot indexes of heart rate variability: Relationships with other nonlinear variables. Autonomic Neuroscience. 2013 Oct;177(2):271–4. doi:10.1016/j.autneu.2013.05.004 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/652-02-006