Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
504-02-003 ISMRM Abstract

Altered Developmental Trajectories and Behavioral Correlates After Repetitive Mild Traumatic Brain Injury in Adolescent Rats

Primary: Neuro - Traumatic Brain Injury
Secondary: Diffusion - Microstructure
504-02-003 · Probing Brain Microstructure with Water: Applications · Wednesday, 13 May, 8:20 AM–10:10 AM · Ballroom East
Keywords: Adolescents Microstructure Diffusion Tensor Imaging (DTI) Repetitive mild traumatic brain injury Behavior
Accepted
Pin-Hui Kuo 1, Yun-Yun Liu1, Huai-An Kuo2, Bao-Yu Hsieh3, Chia-Feng Lu1, Yu-Chieh Jill Kao1
1Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan
2School of Medical Sciences, University of Sydney, Camperdown, Australia
3Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan
Presenting Author: Pin-Hui Kuo

Synopsis

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References

1. Fidan, E., et al., Metabolic and Structural Imaging at 7 Tesla After Repetitive Mild Traumatic Brain Injury in Immature Rats. ASN Neuro, 2018. 10: p. 1759091418770543.
2. Post, A., et al., Pediatric concussion: biomechanical differences between outcomes of transient and persistent (> 4 weeks) postconcussion symptoms. Journal of Neurosurgery: Pediatrics PED, 2017. 19(6): p. 641-651.
3. Hoogenboom, W.S., et al., Evolving brain and behaviour changes in rats following repetitive subconcussive head impacts. Brain Commun, 2023. 5(6): p. fcad316.
4. Cheng, C., et al., Anisotropy component of DTI reveals long-term neuroinflammation following repetitive mild traumatic brain injury in rats. Eur Radiol Exp, 2024. 8(1): p. 82.
5. Mychasiuk, R., H. Hehar, and M.J. Esser, A mild traumatic brain injury (mTBI) induces secondary attention-deficit hyperactivity disorder-like symptomology in young rats. Behavioural Brain Research, 2015. 286: p. 285-292.
6. Pham, L., et al., Behavioral, axonal, and proteomic alterations following repeated mild traumatic brain injury: Novel insights using a clinically relevant rat model. Neurobiol Dis, 2021. 148: p. 105151.
7. Ciganok-Hückels, N., et al., Postnatal development of electrophysiological and morphological properties in layer 2/3 and layer 5 pyramidal neurons in the mouse primary visual cortex. Cereb Cortex, 2023. 33(10): p. 5875-5884.
8. Kroenke, C.D., Using diffusion anisotropy to study cerebral cortical gray matter development. J Magn Reson, 2018. 292: p. 106-116.
9. Christensen, J., et al., Traumatic brain injury in adolescence: A review of the neurobiological and behavioural underpinnings and outcomes. Developmental Review, 2021. 59: p. 100943.
10. Lebel, C. and C. Beaulieu, Longitudinal development of human brain wiring continues from childhood into adulthood. J Neurosci, 2011. 31(30): p. 10937-47.
11. Tu, T.-W., et al., Radiological–pathological correlation of diffusion tensor and magnetization transfer imaging in a closed head traumatic brain injury model. Annals of Neurology, 2016. 79(6): p. 907-920.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/504-02-003