Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
468-01-016 ISMRM Abstract

Higher fasting brain glucose is associated with lower gray matter volume in healthy adults

Primary: Contrast Mechanisms - Spectroscopy
Secondary: Neuro - Aging
468-01-016 · Quantitative Neuroimaging of Neurodegeneration, Metabolism, and Brain Microstructure · Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row I
Keywords: Atrophy MRS Glucose metabolism Structural and Functional MRI Aging trajectories
Accepted
Helena van Nieuwenhuizen1,2, Botond B Antal3,4, Antoine Hone-Blanchet4, Andrew Lithen2, Liam McMahon2, Bruce Jenkins2, Eva-Maria Ratai 4,5, Lilianne Mujica-Parodi2,6
1Stony Brook University, Stony Brook, United States of America
2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America
3Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, United States of America
4Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America
5Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America
6Biomedical Engineering, Stony Brook University, Stony Brook, United States of America
Presenting Author: Eva-Maria Ratai

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References

1. Mortby, Moyra E., et al. "High “normal” blood glucose is associated with decreased brain volume and cognitive performance in the 60s: the PATH through life study." PloS one 8.9 (2013): e73697. https://doi.org/10.1371/journal.pone.0073697 [doi]
2. Cherbuin, Nicolas, Perminder Sachdev, and Kaarin J. Anstey. "Higher normal fasting plasma glucose is associated with hippocampal atrophy: The PATH Study." Neurology 79.10 (2012): 1019-1026. https://doi.org/10.1212/WNL.0b013e31826846de [doi]
3. Cunnane, Stephen, et al. "Brain fuel metabolism, aging, and Alzheimer’s disease." Nutrition 27.1 (2011): 3-20. https://doi.org/10.1016/j.nut.2010.07.021 [doi]
4. Mosso, Jessie, et al. "PET CMRglc mapping and 1H-MRS show altered glucose uptake and neurometabolic profiles in BDL rats." Analytical Biochemistry 647 (2022): 114606. https://doi.org/10.1016/j.ab.2022.114606 [doi]
5. Cooper, Melissa L., et al. "Redistribution of metabolic resources through astrocyte networks mitigates neurodegenerative stress." Proceedings of the National Academy of Sciences 117.31 (2020): 18810-18821. https://doi.org/10.1073/pnas.2009425117 [doi]
6. Antal, Botond B., et al. "Brain aging shows nonlinear transitions, suggesting a midlife “critical window” for metabolic intervention." Proceedings of the National Academy of Sciences 122.10 (2025): e2416433122. https://doi.org/10.1073/pnas.2416433122 [doi]
7. Brownlee, MD, Michael. "Advanced protein glycosylation in diabetes and aging." Annual review of medicine 46.1 (1995): 223-234. https://doi.org/10.1146/annurev.med.46.1.223 [doi]
8. Singh, Varun Parkash, et al. "Advanced glycation end products and diabetic complications." The Korean journal of physiology & pharmacology: official journal of the Korean Physiological Society and the Korean Society of Pharmacology 18.1 (2014): 1. https://doi.org/10.4196/kjpp.2014.18.1.1 [doi]
9. Convit, Antonio, et al. "Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly." Proceedings of the National Academy of Sciences 100.4 (2003): 2019-2022. https://doi.org/10.1073/pnas.0336073100 [doi]

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http://echo.ismrm.org/p/ISMRM2026/468-01-016