Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
464-03-009 ISMRM Abstract

Basal Ganglia and Thalamic Structural Disconnection in Hereditary Spastic Paraplegia Type 4: A Diffusion MRI Connectome Study

Primary: Neuro - Other Neurodegeneration
Secondary: Diffusion - Tractography
464-03-009 · Neurodegenerative Diseases · Tuesday, 12 May, 1:40 PM–2:35 PM · Digital Posters Row E
Keywords: Neurodegeneration Structural Connectivity Graph theory analysis Diffusion Tensor Imaging (DTI) Hereditary spastic paraplegia
Accepted
Francesca Punzetti 1, Alessia Quinzi1, Magali Jane Rochat1, Gianfranco Vornetti1,2, Giovanni Rizzo3, Veria Vacchiano2, Rocco Liguori2,3, Raffaele Lodi1,2, Caterina Tonon1,2
1Programma Neuroimmagini Funzionali e Molecolari, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
2Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy
3Clinica Neurologica, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
Presenting Author: Francesca Punzetti

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Fink, J. K. (2013). Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms. Acta Neuropathologica, 126(3), 307–328. doi: 10.1007/s00401-013-1115-8 [doi]
2. Lo Giudice, T., Lombardi, F., Santorelli, F. M., Kawarai, T., & Orlacchio, A. (2014). Hereditary spastic paraplegia: Clinical-genetic characteristics and evolving molecular mechanisms. Experimental Neurology, 261, 518–539. doi: 10.1016/j.expneurol.2014.06.011 [doi]
3. Castelnovo, V., Canu, E., De Mattei, F., Filippi, M., & Agosta, F. (2023). Basal ganglia alterations in amyotrophic lateral sclerosis. Frontiers in Neuroscience, 17, 1133758. doi: 10.3389/fnins.2023.1133758 [doi]
4. Finegan, E., Hi Shing, S. L., Chipika, R. H., McKenna, M. C., Doherty, M. A., Hengeveld, J. C., … Bede, P. (2020). Thalamic, hippocampal and basal ganglia pathology in primary lateral sclerosis and amyotrophic lateral sclerosis: Evidence from quantitative imaging data. Data in Brief, 29, 105115. doi: 10.1016/j.dib.2020.105115 [doi]
5. Lanciego, J. L., Luquin, N., & Obeso, J. A. (2012). Functional Neuroanatomy of the Basal Ganglia. Cold Spring Harbor Perspectives in Medicine, 2(12), a009621–a009621. doi: 10.1101/cshperspect.a009621 [doi]
6. Faber, I., Martinez, A. R. M., De Rezende, T. J. R., Martins, C. R., Martins, M. P., Lourenço, C. M., … França, M. C. (2018). SPG11 mutations cause widespread white matter and basal ganglia abnormalities, but restricted cortical damage. NeuroImage: Clinical, 19, 848–857. doi: 10.1016/j.nicl.2018.05.031 [doi]
7. da Graça, F. F., de Rezende, T. J. R., Vasconcellos, L. F. R., Pedroso, J. L., Barsottini, O. G. P., & França, M. C. (2019). Neuroimaging in Hereditary Spastic Paraplegias: Current Use and Future Perspectives. Frontiers in Neurology, 9. doi: 10.3389/fneur.2018.01117 [doi]
8. Navas-Sánchez, F. J., Fernández-Pena, A., Martín De Blas, D., Alemán-Gómez, Y., Marcos-Vidal, L., Guzmán-de-Villoria, J. A., … Desco, M. (2021). Thalamic atrophy in patients with pure hereditary spastic paraplegia type 4. Journal of Neurology, 268(7), 2429–2440. doi: 10.1007/s00415-020-10387-4 [doi]
9. Basaia, S., Agosta, F., Cividini, C., Trojsi, F., Riva, N., Spinelli, E. G., … Filippi, M. (2020). Structural and functional brain connectome in motor neuron diseases: A multicenter MRI study. Neurology, 95(18). doi: 10.1212/WNL.0000000000010731 [doi]
10. Spinelli, E. G., Ghirelli, A., Basaia, S., Canu, E., Castelnovo, V., Cividini, C., … Agosta, F. (2024). Structural and Functional Brain Network Connectivity at Different King’s Stages in Patients With Amyotrophic Lateral Sclerosis. Neurology, 102(2), e207946. doi: 10.1212/WNL.0000000000207946 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/464-03-009