Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
469-04-001 ISMRM Abstract

Condition-Specific Patterns of Muscle Health in Chronic Pain: A UK Biobank Normative Modeling Study

Primary: Musculoskeletal - Muscle
Secondary: Body - Body Composition
469-04-001 · MRI and MRS in Muscle in Health and Disease · Tuesday, 12 May, 2:35 PM–3:30 PM · Digital Posters Row J
Keywords: Muscle Musculoskeletal MRI Normative modeling Chronic pain Muscle composition
Accepted
Merve Kaptan1, Yiyu Wang1, Ananya Goyal2, Skylar Holmes2, Dean A Dennis3, Sandrine Bédard4,5, Garry E Gold2, Akshay Chaudhari2,6, Anoosha Pai S2, Kerem Ozkan1, Anthony A Gatti2, Suzanne Tharin7, Feliks Kogan2,8, Christine S W Law1, John Ratliff7, Serena Hu9, Brian A Hargreaves2,10,11,12,13, Anand Veeravagu7, Atman Desai7, Scott Delp13,14, Marnee J McKay15, Hugo Decker16, Andrew Smith17, Dario Pfyffer1, Joel Fundaun1, Brian Kim15, Estifanos Berhe1, Robert Walsh3, Alec Schielke3, Todd Alamin9, Benjamin De Leener18,19,20,21,22,23, Julien Cohen-Adad18,24,25,26, Zachary A Smith27, Fauziyya Muhammad27, James M Elliott28,29, Sean Mackey1, Evert Onno WEsselink1, Kenneth Weber 1
1Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, United States of America
2Department of Radiology, Stanford University, Stanford, United States of America
3Chiropractic Section, Integrated Primary Care Service, VA Palo Alto, Palo Alto, United States of America
4Polytechnique Montréal, Montréal, Canada
5NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montréal, Montréal, Canada
6Biomedical Data Science, Stanford University, Stanford, United States of America
7Department of Neurosurgery, Stanford Medicine, Stanford, United States of America
8Stanford University, Stanford, United States of America
9Department of Orthopaedic Surgery, Stanford Medicine, Stanford, United States of America
10Electrical Engineering, Stanford University, Stanford, United States of America
11Bioengineering, Stanford University, Stanford, United States of America
12Department of Electrical Engineering, Stanford University, Stanford, United States of America
13Department of Bioengineering, Stanford University, Stanford, United States of America
14Department of Mechanical Engineering, Stanford University, Stanford, United States of America
15Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia
16Division of Neuroimaging and Neurointervention, Department of Radiology, Stanford Medicine, Stanford, United States of America
17Physical Therapy Program, Department of Physical Medicine and Rehabilitation, School of Medicine, University of Colorado, Aurora, United States of America
18NeuroPoly Lab, Montreal, Canada
19Research Center, Ste-Justine Hospital University Centre, Montreal, Canada
20Department of Computer Engineering and Software Engineering, Polytechnique Montréal, Montréal, Canada
21CHU Sainte-Justine Research Center, Montréal, Canada, Canada
22Department of Computer Engineering and Software Engineering, Polytechnique Montreal, Montreal, Canada, Canada
23NeuroPoly Lab, Institute of Biomedical Engineering,, Polytechnique Montréal, Montréal, Canada
24Mila - Quebec AI Institute, Montreal, Canada
25Functional Neuroimaging Unit, Montreal, Canada
26Centre de Recherche du CHU Sainte-Justine, Montreal, Canada
27Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, United States of America
28The Kolling Institute, Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia
29Northern Sydney Local Health District, The University of Sydney, Sydney, Australia
Presenting Author: Kenneth Weber

Synopsis

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References

1. Masnoon, N., Cornwall, J., Elliott, J. M., Glare, P., Hilmer, S. N., McKay, M., Walton, D. M., Weber, K., & Wesselink, E. (2025). Muscle Composition as a Novel Prognostic Tool for Pain, Frailty, and Sarcopenia. Clinics in Geriatric Medicine, 0(0). https://doi.org/10.1016/j.cger.2025.08.012 [doi]
2. Verbunt, J. A., Smeets, R. J., & Wittink, H. M. (2010). Cause or effect? Deconditioning and chronic low back pain. PAIN, 149(3), 428–430. https://doi.org/10.1016/j.pain.2010.01.020 [doi]
3. McKay, M. J., Weber, K. A., Wesselink, E. O., Smith, Z. A., Abbott, R., Anderson, D. B., Ashton-James, C. E., Atyeo, J., Beach, A. J., Burns, J., Clarke, S., Collins, N. J., Coppieters, M. W., Cornwall, J., Crawford, R. J., De Martino, E., Dunn, A. G., Eyles, J. P., Feng, H. J., … Elliott, J. M. (2024). MuscleMap: An Open-Source, Community-Supported Consortium for Whole-Body Quantitative MRI of Muscle. Journal of Imaging, 10(11), 262. https://doi.org/10.3390/jimaging10110262 [doi]
4. (ISMRM 2025) Segment-Any-Muscle: Towards an Open-Source, Contrast-Agnostic Computer-Vision Muscle Segmentation Model for MRI and CT. (Wesselink, E, …, Weber, K. A.,). Retrieved October 3, 2025, from https://archive.ismrm.org/2025/0622_M5Zhn5RCU.html
5. https://github.com/MuscleMap/MuscleMap
6. Rutherford, S., Kia, S. M., Wolfers, T., Fraza, C., Zabihi, M., Dinga, R., Berthet, P., Worker, A., Verdi, S., Ruhe, H. G., Beckmann, C. F., & Marquand, A. F. (2022). The normative modeling framework for computational psychiatry. Nature Protocols, 17(7), 1711–1734. https://doi.org/10.1038/s41596-022-00696-5 [doi]
7. Marquand, A. F., Wolfers, T., Mennes, M., Buitelaar, J., & Beckmann, C. F. (2016). Beyond Lumping and Splitting: A Review of Computational Approaches for Stratifying Psychiatric Disorders. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 1(5), 433–447. https://doi.org/10.1016/j.bpsc.2016.04.002 [doi]

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http://echo.ismrm.org/p/ISMRM2026/469-04-001