666-03-007 ISMRM Abstract

Enhanced neurometabolic activity in Leprdb/db Mouse Model of Type 2 Diabetes: A ¹H-[¹³C]-NMR Study

Primary: Preclinical Animal & in vitro MR - Biology, Models, Methods

Secondary: Neuro - Aging

666-03-007 · Neuro-Biomarkers · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row G

Keywords: Gamma-aminobutyric acid Glutamate 1H-13C-NMR Acetate Metabolism Beta-hydroxybutyrate

Accepted

Anant B Patel ¹, Shalini Vidyadharan¹, Jerald Mahesh Kumar²

¹NMR MICROIMAGING AND SPECTROSCOPY, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India

²Animal House Facility, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India

Presenting Author: Anant B Patel

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References

1. Zhao, X., Han, Q., Gang, X., & Wang, G. (2018). Altered brain metabolites in patients with diabetes mellitus and related complications – evidence from 1H MRS study. Bioscience Reports, 38(5), BSR20180660. https://doi.org/10.1042/BSR20180660 [doi]

2. Garcia-Serrano, A. M., & Duarte, J. M. N. (2020). Brain Metabolism Alterations in Type 2 Diabetes: What Did We Learn From Diet-Induced Diabetes Models? Frontiers in Neuroscience, 14, 229. https://doi.org/10.3389/fnins.2020.00229 [doi]

3. Gould, T. D., Dao, D. T. & Kovacsics, C. E. The Open Field Test. in Mood and Anxiety Related Phenotypes in Mice (ed. Gould, T. D.) vol. 42 1–20 (Humana Press, 2009).

4. Chowdhury, G. M., Jiang, L., Rothman, D. L., & Behar, K. L. (2014). The contribution of ketone bodies to basal and activity-dependent neuronal oxidation in vivo. J Cereb Blood Flow Metab, 34(7), 1233-1242. https://doi.org/10.1038/jcbfm.2014.77 [doi]

5. De Graaf RA, Brown PB, Mason GF, Rothman DL, Behar KL. (2003). Detection of [1,6-13C2]-glucose metabolism in rat brain

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http://echo.ismrm.org/p/ISMRM2026/666-03-007