Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
666-03-013 ISMRM Abstract

Age-Related Volumetric Brain Alterations from Early Adulthood to Mid-Life in Female Wistar Rats

Primary: Preclinical Animal & in vitro MR - Small Animals
Secondary: Analysis Methods - Segmentation and Detection
666-03-013 · Neuro-Biomarkers · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row G
Keywords: Aging 7T Volume measurement Preclinical MRI Preprocessing pipeline
Accepted
Leen HAKKI 1, Belal TAVASHI1, Uluç Pamuk1, Ayşenur Gök1, Esin Ozturk Isik1,2, Pinar S Özbay1
1Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey
2Brain Tumor Research Group, Acibadem University, Istanbul, Turkey
Presenting Author: Leen HAKKI

Synopsis

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References

1. Hamezah HS, Durani LW, Ibrahim NF, et al. Volumetric changes in the aging rat brain and its impact on cognitive and locomotor functions. Experimental Gerontology. 2017;99:69-79. doi:10.1016/j.exger.2017.09.008 [doi]
2. Hedman AM, Van Haren NEM, Schnack HG, Kahn RS, Pol HEH. Human brain changes across the life span: A review of 56 longitudinal magnetic resonance imaging studies. Human Brain Mapping. 2011;33(8):1987-2002. doi:10.1002/hbm.21334 [doi]
3. MacNicol E, Wright P, Kim E, et al. Age-Specific Adult rat brain MRI templates and tissue probability maps. Frontiers in Neuroinformatics. 2022;15. doi:10.3389/fninf.2021.669049 [doi]
4. Lebel C, Beaulieu C. Longitudinal Development of Human Brain Wiring Continues from Childhood into Adulthood. Journal of Neuroscience. 2011;31(30):10937-10947. doi:10.1523/jneurosci.5302-10.2011 [doi]
5. Gull S, Gaser C, Herrmann KH, et al. Brain Macro-Structural Alterations in aging rats: a Longitudinal Lifetime approach. Cells. 2023;12(3):432. doi:10.3390/cells12030432 [doi]
6. MacNicol E, Wright P, Kim E, et al. Age-Specific Adult rat brain MRI templates and tissue probability maps. Frontiers in Neuroinformatics. 2022;15. doi:10.3389/fninf.2021.669049 [doi]
7. Barrière DA, Magalhães R, Novais A, et al. The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization. Nature Communications. 2019;10(1). doi:10.1038/s41467-019-13575-7 [doi]
8. Avants BB, Tustison NJ, Song G, Cook PA, Klein A, Gee JC. A reproducible evaluation of ANTs similarity metric performance in brain image registration. NeuroImage. 2010;54(3):2033-2044. doi:10.1016/j.neuroimage.2010.09.025 [doi]
9. Ashburner J, Friston KJ. Unified segmentation. NeuroImage. 2005;26(3):839-851. doi:10.1016/j.neuroimage.2005.02.018 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/666-03-013