Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
460-05-011 ISMRM Abstract

How sleep disorder affect glymphatic circulation and network efficiency in internet gaming disorder: Insights from a DTI-ALPS

Primary: Neuro - Psychiatric Disorders
Secondary: Brain Function and fMRI - fMRI Analysis
460-05-011 · When Brain Clearance Fails: Glymphatic Dysfunction Across Disorders · Tuesday, 12 May, 4:00 PM–4:55 PM · Digital Posters Row A
Keywords: Internet Gaming Disorder Sleep disorders Graph theory analysis Glymphatic system (GS) DTI-ALPS index
Accepted
Longyao Ma 1, Bohui Mei2, Mengzhe Zhang2, Wenjing Li3, Xinyu Wang3, Shaoqiang Han3, Yong Zhang2
1The Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
2Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
3Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Presenting Author: Longyao Ma

Synopsis

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References

1. Alimoradi, Z., C. Y. Lin, A. Broström, P. H. Bülow, Z. Bajalan, M. D. Griffiths, M. M. Ohayon and A. H. Pakpour (2019). "Internet addiction and sleep problems: A systematic review and meta-analysis." Sleep Med Rev 47: 51-61.
2. Kashfi, S. M., H. Karami, F. Jafari, M. Daliri, M. Yazdankhah, A. Kamyab and A. Khani Jeihooni (2023). "Internet Addiction and Sleep Disorders among Medical Students." ScientificWorldJournal 2023: 6685676.
3. Chen, R. F., Y. Cai, Z. H. Zhu, W. L. Hou, P. Chen, J. Wang, Y. M. Jia, Z. B. Zhu, Y. H. Zhang, L. Y. Tao, J. W. Wu, J. Zhang, H. Zhang, Z. X. Wang, Q. F. Jia and L. Hui (2022). "Sleep disorder as a clinical risk factor of major depression: associated with cognitive impairment." Asian J Psychiatr 76: 103228.
4. Pearson, O., N. Uglik-Marucha, K. W. Miskowiak, S. A. Cairney, I. Rosenzweig, A. H. Young and P. R. A. Stokes (2023). "The relationship between sleep disturbance and cognitive impairment in mood disorders: A systematic review." J Affect Disord 327: 207-216.
5. Bishir, M., A. Bhat, M. M. Essa, O. Ekpo, A. O. Ihunwo, V. P. Veeraraghavan, S. K. Mohan, A. M. Mahalakshmi, B. Ray, S. Tuladhar, S. Chang, S. B. Chidambaram, M. K. Sakharkar, G. J. Guillemin, M. W. Qoronfleh and D. M. Ojcius (2020). "Sleep Deprivation and Neurological Disorders." Biomed Res Int 2020: 5764017.
6. Eugene, A. R. and J. Masiak (2015). "The Neuroprotective Aspects of Sleep." MEDtube Sci 3(1): 35-40.
7. Taoka, T., Y. Masutani, H. Kawai, T. Nakane, K. Matsuoka, F. Yasuno, T. Kishimoto and S. Naganawa (2017). "Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases." Jpn J Radiol 35(4): 172-178.
8. Hablitz, L. M. and M. Nedergaard (2021). "The Glymphatic System: A Novel Component of Fundamental Neurobiology." J Neurosci 41(37): 7698-7711.
9. Shetty, A. K. and G. Zanirati (2020). "The Interstitial System of the Brain in Health and Disease." Aging Dis 11(1): 200-211.
10. Iliff, J. J., M. J. Chen, B. A. Plog, D. M. Zeppenfeld, M. Soltero, L. Yang, I. Singh, R. Deane and M. Nedergaard (2014). "Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury." J Neurosci 34(49): 16180-16193.
11. Kaess, M., P. Parzer, L. Mehl, L. Weil, E. Strittmatter, F. Resch and J. Koenig (2017). "Stress vulnerability in male youth with Internet Gaming Disorder." Psychoneuroendocrinology 77: 244-251.
12. Tsumura, H., M. Fukuda and H. Kanda (2022). "Blunted cortisol and normal sympathetic nervous system responses to an acute psychosocial stressor in internet addiction." Heliyon 8(12): e12142.
13. Mastorakos, G. and I. Ilias (2006). "Interleukin-6: a cytokine and/or a major modulator of the response to somatic stress." Ann N Y Acad Sci 1088: 373-381.
14. Hassamal, S. (2023). "Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories." Front Psychiatry 14: 1130989.
15. Wei, F., J. Song, C. Zhang, J. Lin, R. Xue, L. D. Shan, S. Gong, G. X. Zhang, Z. H. Qin, G. Y. Xu and L. H. Wang (2019). "Chronic stress impairs the aquaporin-4-mediated glymphatic transport through glucocorticoid signaling." Psychopharmacology (Berl) 236(4): 1367-1384.
16. Zou, K., Q. Deng, H. Zhang and C. Huang (2024). "Glymphatic system: a gateway for neuroinflammation." Neural Regen Res 19(12): 2661-2672.
17. Hablitz, L. M., V. Plá, M. Giannetto, H. S. Vinitsky, F. F. Stæger, T. Metcalfe, R. Nguyen, A. Benrais and M. Nedergaard (2020). "Circadian control of brain glymphatic and lymphatic fluid flow." Nat Commun 11(1): 4411.
18. Liu, D. X., X. He, D. Wu, Q. Zhang, C. Yang, F. Y. Liang, X. F. He, G. Y. Dai, Z. Pei, Y. Lan and G. Q. Xu (2017). "Continuous theta burst stimulation facilitates the clearance efficiency of the glymphatic pathway in a mouse model of sleep deprivation." Neurosci Lett 653: 189-194.

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http://echo.ismrm.org/p/ISMRM2026/460-05-011