Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
664-02-004 ISMRM Abstract

Evaluating lipid-sensitive MRI for mapping lipid composition in the developing marmoset brain

Primary: Preclinical Animal & in vitro MR - Large Animals, Nonhuman Primates
Secondary: Neuro - Development
664-02-004 · Large Animals · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row E
Keywords: CEST / APT / NOE Marmoset Brain Development Short-T2 Lipid composition
Accepted
Anshuman Swain1, Tianjia Zhu2,3,4, Ziqin Zhang3,5, Keshav Menon1, Narayan Datt Soni1,5,6,7, Paul S Jacobs1,5,6,7, RAVI PRAKASH REDDY NANGA1,5, Mohammad Haris1,5,7, Hao Huang2,3,5,6,8,9, Ravinder Reddy1,5,6,7,10,11
1Department of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine (CAMIPM), University of Pennsylvania, Philadelphia, United States of America
2Radiology, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Bioengineering, University of Pennsylvania, Philadelphia, United States of America
5University of Pennsylvania, Philadelphia, United States of America
6Department of Radiology, University of Pennsylvania, Philadelphia, United States of America
7Center for Advanced Metabolic Imaging in Precision Medicine, Philadelphia, United States of America
8Radiology, University of Pennsylvania, Philadelphia, United States of America
9Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, United States of America
10Center for Advanced Metabolic Imaging in Precision Medicine, Center for Advanced Metabolic Imaging in Precision Medicine, Philadelphia, United States of America
11Center for Advanced Metabolic Imaging in Precision Medicine, University of Pennsylvania, Philadelphia, United States of America
Presenting Author: Blake A Benyard

Synopsis

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References

1. Hussain G, Wang J, Rasul A, Anwar H, Imran A, Qasim M, et al. Role of cholesterol and sphingolipids in brain development and neurological diseases. Lipids Health Dis. 2019;18(1):26. 10.1186/s12944-019-0965-z [doi]
2. Carlson SE. Early determinants of development: a lipid perspective. Am J Clin Nutr. 2009;89(5):1523S-9S. 10.3945/ajcn.2009.27113G [doi]
3. Yoon JH, Seo Y, Jo YS, Lee S, Cho E, Cazenave-Gassiot A, et al. Brain lipidomics: From functional landscape to clinical significance. Sci Adv. 2022;8(37):eadc9317. 10.1126/sciadv.adc9317 [doi]
4. Swain A, Soni ND, Wilson N, Juul H, Benyard B, Haris M, et al. Early-stage mapping of macromolecular content in APP(NL-F) mouse model of Alzheimer's disease using nuclear Overhauser effect MRI. Front Aging Neurosci. 2023;15:1266859. 10.3389/fnagi.2023.1266859 [doi]
5. Swain A, Soni ND, Wilson N, Reddy R. Frequency-selective inversion nulling ultra-short echo time (FINUTE) MRI for direct detection of lipids of the myelin bilayer.
6. Sanjeeva Reddy T, Rajalakshmi R, Ramakrishnan CV. Lipid composition of gray and white matter in developing rat brain. Int J Dev Neurosci. 1983;1(1):65-74. 10.1016/0736-5748(83)90012-6 [doi]
7. Li Q, Bozek K, Xu C, Guo Y, Sun J, Paabo S, et al. Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys. Mol Biol Evol. 2017;34(5):1155-66. 10.1093/molbev/msx065 [doi]
8. Shin SH, Moazamian D, Suprana A, Zeng C, Athertya JS, Carl M, et al. Yet more evidence that non-aqueous myelin lipids can be directly imaged with ultrashort echo time (UTE) MRI on a clinical 3T scanner: a lyophilized red blood cell membrane lipid study. Neuroimage. 2024;296:120666. 10.1016/j.neuroimage.2024.120666 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/664-02-004