Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
463-02-012 ISMRM Abstract

Enhancing Post-Stroke Motor Recovery with Ventrolateral Thalamus DBS via Neuroplastic Remodeling Revealed by DTI in PTI Model

Primary: Neuro - Stroke and Cerebrovascular Disorders
Secondary: Preclinical Animal & in vitro MR - Small Animals
463-02-012 · Imaging Stroke Recovery: From Microstructure to Personalized Therapy · Tuesday, 12 May, 9:15 AM–10:10 AM · Digital Posters Row D
Keywords: Deep Brain Stimulation Motor Recovery Neuroplasticity Ischemic Stroke Ventrolateral Thalamus
Accepted
Cheng-Ru Yang 1, Yao-Wen Liang1, Ssu-Ju Li1, Ting-Chieh Chen1, Ching-Wen Chang1, Yu-Qian Ke1, Yi-Duan Chen2, Yi-Ren Lin3, Zhi-Shin Cheng3, Sheng-Huang Lin4,5, You-Yin Chen1,6
1Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan
2Department of Respiratory Therapy, Taipei Medical University, Taipei, Taiwan
3School of Gerontology and Long-Term Care, Taipei Medical University, Taipei, Taiwan
4Department of Neurology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan
5Department of Neurology, School of Medicine, Tzu Chi University, Hualien, Taiwan
6Ph.D. Program In Medical Neuroscience, Taipei Medical University, Taipei, Taiwan
Presenting Author: Cheng-Ru Yang

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References

1. Bao SC, Khan A, Song R, Kai-Yu Tong R. Rewiring the Lesioned Brain: Electrical Stimulation for Post-Stroke Motor Restoration. J Stroke. Jan 2020;22(1):47-63. doi:10.5853/jos.2019.03027 [doi]
2. Patel J, Qiu Q, Fluet GG, et al. A randomized controlled trial of timing and dosage of upper extremity rehabilitation in virtual environments in persons with subacute stroke. Scientific Reports. 2025/04/22 2025;15(1):13834. doi:10.1038/s41598-025-98618-4 [doi]
3. Baker KB, Plow EB, Nagel S, et al. Cerebellar deep brain stimulation for chronic post-stroke motor rehabilitation: a phase I trial. Nat Med. Sep 2023;29(9):2366-2374. doi:10.1038/s41591-023-02507-0 [doi]
4. Guo J, Zhang H, Liu J, et al. Thalamic functional dysconnectivity in patients with left-hemisphere chronic capsular and pontine stroke. Frontiers in Neuroscience. 2024;18:1451307. https://doi.org/10.3389/fnins.2024.1451307 [doi]
5. Seibenhener ML, Wooten MC. Use of the Open Field Maze to measure locomotor and anxiety-like behavior in mice. J Vis Exp. Feb 6 2015;(96):e52434. doi:10.3791/52434 [doi]
6. Schallert T, Fleming SM, Leasure JL, Tillerson JL, Bland ST. CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury. Neuropharmacology. 2000;39(5):777-787. doi: 10.1016/s0028-3908(00)00005-8 [doi]
7. Li C-X, Meng Y, Yan Y, et al. Investigation of White Matter and Grey Matter Alterations in the Monkey Brain Following Ischemic Stroke Using Diffusion Tensor Imaging. Investig Magn Reson Imaging. 12/ 2022;26(4):275-283. doi: 10.13104/imri.2022.26.4.275 [doi]
8. Li S, Rao JH, Lan XY, et al. White matter demyelination predates axonal injury after ischemic stroke in cynomolgus monkeys. Exp Neurol. Jun 2021;340:113655. doi:10.1016/j.expneurol.2021.113655 [doi]
9. Park HJ, Furmaga H, Cooperrider J, Gale JT, Baker KB, Machado AG. Modulation of Cortical Motor Evoked Potential After Stroke During Electrical Stimulation of the Lateral Cerebellar Nucleus. Brain Stimul. Nov-Dec 2015;8(6):1043-8. doi:10.1016/j.brs.2015.06.020 [doi]
10. Cooperrider J, Furmaga H, Plow E, et al. Chronic deep cerebellar stimulation promotes long-term potentiation, microstructural plasticity, and reorganization of perilesional cortical representation in a rodent model. J Neurosci. Jul 2 2014;34(27):9040-50. doi:10.1523/jneurosci.0953-14.2014 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/463-02-012