Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
666-03-009 ISMRM Abstract

Non-invasive Detection of Region-Specific Glutamatergic Alterations in Alcohol-Exposed Mice Using 7 T GluCEST MRI

Primary: Preclinical Animal & in vitro MR - Biomarkers
Secondary: Preclinical Animal & in vitro MR - Small Animals
666-03-009 · Neuro-Biomarkers · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row G
Keywords: Acquisition Methods Brain CEST & MT Metabolism Addiction
Accepted
Rico Singer 1, Pilar Ortiz-Teba1, Cameron Luzi1, Thomas Baillot1, Marion RAME1, Julien Lamy1, Laura-Adela HARSAN1,2
1IMIS (Integrative Multimodal Imaging in Healthcare) Team, ICube, CNRS, Université de Strasbourg, Strasbourg, France
2Department of Biophysics and Nuclear Medicine, University Hospital of Strasbourg, Strasbourg, France
Presenting Author: Rico Singer

Synopsis

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References

1. “Global status report on alcohol and health and treatment of substance use disorders,” World Health Organization, Geneva, 2024.
2. Z. Wang, X. Zhu, X. Ni, Y. Wen, and D. Shang, “Knowledge atlas of the involvement of glutamate and GABA in alcohol use disorder: A bibliometric and scientometric analysis,” Front Psychiatry, vol. 13, p. 965142, Aug. 2022, doi: 10.3389/fpsyt.2022.965142. [doi]
3. S. Carboni, R. Isola, G. L. Gessa, and Z. L. Rossetti, “Ethanol prevents the glutamate release induced by N-methyl-d-aspartate in the rat striatum,” Neuroscience Letters, vol. 152, no. 1, pp. 133–136, Apr. 1993, doi: 10.1016/0304-3940(93)90501-B. [doi]
4. J. T. Gale, D. C. Shields, Y. Ishizawa, and E. N. Eskandar, “Reward and reinforcement activity in the nucleus accumbens during learning,” Front Behav Neurosci, vol. 8, p. 114, Apr. 2014, doi: 10.3389/fnbeh.2014.00114. [doi]
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6. A. E. Chan, J. Q. Anderson, K. B. Grigsby, B. E. Jensen, A. E. Ryabinin, and A. R. Ozburn, “Sex differences in nucleus accumbens circuitry engaged with binge-like ethanol drinking,” Psychopharmacology (Berl), Aug. 2025, doi: 10.1007/s00213-025-06875-y. [doi]
7. S. P, W. J, R. V, L. Me, B. P, and Z. M, “Simultaneous mapping of water shift and B1 (WASABI)-Application to field-Inhomogeneity correction of CEST MRI data,” Magnetic resonance in medicine, vol. 77, no. 2, Feb. 2017, doi: 10.1002/mrm.26133. [doi]
8. Y. Jia et al., “Glutamate Chemical Exchange Saturation Transfer (GluCEST) Magnetic Resonance Imaging in Pre-clinical and Clinical Applications for Encephalitis,” Front Neurosci, vol. 14, p. 750, July 2020, doi: 10.3389/fnins.2020.00750. [doi]
9. W. C. Griffin III, H. L. Haun, C. L. Hazelbaker, V. S. Ramachandra, and H. C. Becker, “Increased Extracellular Glutamate In the Nucleus Accumbens Promotes Excessive Ethanol Drinking in Ethanol Dependent Mice,” Neuropsychopharmacol, vol. 39, no. 3, pp. 707–717, Feb. 2014, doi: 10.1038/npp.2013.256. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/666-03-009