370-05-038 ISMRM Abstract

Myocardial Mapping of glucose metabolism with Multi-echo 2H bSSFP: Pilot study in humans on a clinical 3T MRI scanner

Primary: Cardiovascular - Inflammation, Infiltration

Secondary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging

370-05-038 · Cardiac Metabolism and Diffusion · Monday, 11 May, 1:50 PM–2:45 PM · Traditional Posters | Exhibition Hall

Keywords: BSSFP Deuterium Metabolic Imaging Cardiovascular magnetic resonance

Accepted

Jie Xiang¹, Robin A de Graaf², Henk M De Feyter², Monique A Thomas², Lauren A Baldassarre^2,3, Jennifer M Kwan³, Albert J Sinusas^2,3, Edward J Miller³, Dana Peters ^1,2

¹Department of Biomedical Engineering, Yale University, New Haven, United States of America

²Department of Radiology and Biomedical Imaging, Yale University, New Haven, United States of America

³Department of Cardiovascular Medicine, Yale University, New Haven, United States of America

Presenting Author: Dana Peters

Synopsis

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References

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2. Wang T, Zhu XH, Li H, et al. Noninvasive assessment of myocardial energy metabolism and dynamics using in vivo deuterium MRS imaging. Magn Reson Med. 2021;86(6):2899-2909. doi:10.1002/mrm.28914 [doi]

3. Cunningham CH, Lau JY, Chen AP, et al. Hyperpolarized 13C Metabolic MRI of the Human Heart: Initial Experience. Circ Res. 2016;119(11):1177-1182. doi:10.1161/CIRCRESAHA.116.309769 [doi]

4. Larson PEZ, Tang S, Liu X, et al. Regional quantification of cardiac metabolism with hyperpolarized [1-13C]-pyruvate CMR evaluated in an oral glucose challenge. J Cardiovasc Magn Reson. 2023;25(1):77. Published 2023 Dec 14. doi:10.1186/s12968-023-00972-7 [doi]

5. De Feyter HM, Behar KL, Corbin ZA, et al. Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo. Sci Adv. 2018;4(8):eaat7314. Published 2018 Aug 22.

6. Peters DC, Markovic S, Bao Q, et al. Improving deuterium metabolic imaging (DMI) signal-to-noise ratio by spectroscopic multi-echo bSSFP: A pancreatic cancer investigation. Magn Reson Med. 2021;86(5):2604-2617.

7. Tsao J, Jiang Y. Hierarchical IDEAL: fast, robust, and multiresolution separation of multiple chemical species from multiple echo times. Magn Reson Med. 2013;70(1):155-159.

8. Xiang J, de Graaf RA, De Feyter HM, et al. Metabolic Myocardial Mapping with Multi-echo bSSFP: Pilot study in humans on a clinical 3T MRI scanner. Proc Intl Soc Magn Reson Med. 2025;33:2902. Honolulu, HI, USA

9. Montrazi ET, Sasson K, Agemy L, et al. High-sensitivity deuterium metabolic MRI differentiates acute pancreatitis from pancreatic cancers in murine models. Sci Rep. 2023;13(1):19998. Published 2023 Nov 15. doi:10.1038/s41598-023-47301-7 [doi]

10. Iyyappan Valsala P, Pohmann R, Heule R, et al. High-resolution deuterium metabolic imaging of the human brain at 9.4 T using phase-cycled balanced SSFP spectral-spatial acquisitions. Magn Reson Med. Published online October 13, 2025. doi:10.1002/mrm.70114 [doi]

11. Frese S, Strasser B, Hingerl L, et al. Balanced Steady-State Free Precession Enables High-Resolution Dynamic 3D Deuterium Metabolic Imaging of the Human Brain at 7T. Invest Radiol. Published online April 25, 2025. doi:10.1097/RLI.0000000000001196 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/370-05-038