Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
562-01-006 ISMRM Abstract

REGIONAL VENTILATION MAPPED BY 3D PHASE-RESOLVED FUNCTIONAL LUNG MRI IMPROVES AFTER BRONCHODILATOR TREATMENT IN SEVERE ASTHMA

Primary: Body - Lung
Secondary: Analysis Methods - Data Processing
562-01-006 · Lung and Thoracic Oncological MRI · Wednesday, 13 May, 8:20 AM–9:15 AM · Digital Posters Row C
Keywords: Treatment Response Repeatability Lung MRI Asthma Bronchodilator
Accepted
Filip Klimeš 1,2,3, Chuan T Foo4,5, Andreas Voskrebenzev1,2, Marius Klein1,2, Richard McIntyre4,6, Frank Wacker1,2, Jens Vogel-Claussen1,2,3, Francis Thien4,5
1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany
2Member of the German Centre for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease, Hannover, Germany
3Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
4Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia
5Department of Respiratory Medicine, Eastern Health, Box Hill, Australia
6Monash Biomedical Imaging, Monash University, Melbourne, Australia
Presenting Author: Filip Klimeš

Synopsis

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References

1. Matera MG, Page CP, Calzetta L, Rogliani P, Cazzola M. Pharmacology and therapeutics of bronchodilators revisited. Pharmacol Rev. 2020;72(1):218-252. doi:10.1124/pr.119.018150 [doi]
2. Wells KE, Peterson EL, Ahmedani BK, Severson RK, Gleason-Comstock J, Williams LK. The relationship between combination inhaled corticosteroid and long-acting β-agonist use and severe asthma exacerbations in a diverse population. J Allergy Clin Immunol. 2012;129(5):1274-1279.e2. doi:10.1016/j.jaci.2011.12.974 [doi]
3. Klimeš F, Voskrebenzev A, Gutberlet M, et al. 3D phase‐resolved functional lung ventilation MR imaging in healthy volunteers and patients with chronic pulmonary disease. Magn Reson Med. 2021;85(2):912-925. doi:10.1002/mrm.28482 [doi]
4. Klimeš F, Voskrebenzev A, Gutberlet M, et al. Repeatability of dynamic 3D phase-resolved functional lung (PREFUL) ventilation MR Imaging in patients with chronic obstructive pulmonary disease and healthy volunteers. J Magn Reson Imaging. 2021;54(2):618-629. doi:10.1002/jmri.27543 [doi]
5. Klimeš F, Foo CT, Gutberlet M, et al. Dual-Center Repeatability, Consistency, and Comparison of 3D Phase-Resolved Functional (PREFUL) Ventilation MRI at 3 and 1.5 T in Healthy Volunteers. NMR Biomed. 2025;38(9). doi:10.1002/nbm.70101 [doi]
6. Forsberg D. fordanic/image-registration (https://github.com/fordanic/image-registration), GitHub. Retrieved September 8, 2021.
7. Klimeš F, Voskrebenzev A, Gutberlet M, et al. Free‐breathing quantification of regional ventilation derived by phase‐resolved functional lung (PREFUL) MRI. NMR Biomed. 2019;(February):e4088. doi:10.1002/nbm.4088 [doi]
8. Voskrebenzev A, Gutberlet M, Klimeš F, et al. Feasibility of quantitative regional ventilation and perfusion mapping with phase-resolved functional lung (PREFUL) MRI in healthy volunteers and COPD, CTEPH, and CF patients. Magn Reson Med. 2018;79(4):2306-2314. doi:10.1002/mrm.26893 [doi]
9. Pöhler GH, Löffler F, Klimeš F, et al. Validation of Phase-Resolved Functional Lung (PREFUL) Magnetic Resonance Imaging Pulse Wave Transit Time in Healthy Subjects and Chronic Obstructive Pulmonary Disease. J Magn Reson Imaging. 2021:1-11. doi:10.1002/jmri.28016 [doi]
10. Moher Alsady T, Voskrebenzev A, Greer M, et al. MRI‐derived regional flow‐volume loop parameters detect early‐stage chronic lung allograft dysfunction. J Magn Reson Imaging. 2019;50(6):1873-1882. doi:10.1002/jmri.26799 [doi]
11. Svenningsen S, Kirby M, Starr D, et al. Hyperpolarized 3He and 129Xe MRI: Differences in asthma before bronchodilation. J Magn Reson Imaging. 2013;38(6):1521-1530. doi:10.1002/jmri.24111 [doi]
12. Smith L, Marshall H, Biancardi A, et al. Xe-MRI bronchodilator response to assess disease severity in patients with asthma and/or COPD. In: European Respiratory Journal 2023 62(Suppl 67). European Respiratory Society; 2023:PA4500. doi:10.1183/13993003.congress-2023.PA4500 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/562-01-006