Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
364-01-006 ISMRM Abstract

Orbitofrontal TMS Engages Fronto-limbic Circuits Relevant to Depression: Evidence from interleaved TMS-fMRI

Primary: Brain Function and fMRI - fMRI & Neuromodulation
Secondary: Neuro - Neuromodulation
364-01-006 · fMRI: Analyses · Monday, 11 May, 8:20 AM–9:15 AM · Digital Posters Row E
Keywords: Effective Connectivity MR-Guided Interventions TMS-fMRI Orbitofrontal TMS
Accepted
Minyan Huang 1, Michael Woletz1, Severin Schramm2, Maria Vasileiadi3, Onisim Soanca1, Anna-lisa Schuler4, Jonathan Downar5, Martin Tik1
1Medical University of Vienna, Vienna, Austria
2Institute for Diagnostic and Interventional Neuroradiology, School of Medicine and Health, TUM Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
3Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, University of Toronto, Canada, Canada
4Research Group Cognition and Plasticity, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
5Department of Psychiatry and Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada
Presenting Author: Minyan Huang

Synopsis

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References

1. Chen, L., Klooster, D. C. W., Tik, M., Thomas, E. H. X., Downar, J., Fitzgerald, P. B., Williams, N. R., & Baeken, C. (2023). Accelerated repetitive transcranial magnetic stimulation to treat major depression: the past, present, and future. Harvard Review of Psychiatry, 31(3), 142–161. https://doi.org/10.1097/hrp.0000000000000364 [doi]
2. Cole, E. J., Phillips, A. L., Bentzley, B. S., Stimpson, K. H., Nejad, R., Barmak, F., Veerapal, C., Khan, N., Cherian, K., Felber, E., Brown, R., Choi, E., King, S., Pankow, H., Bishop, J. H., Azeez, A., Coetzee, J., Rapier, R., Odenwald, N., . . . Williams, N. R. (2021). Stanford Neuromodulation Therapy (SNT): a Double-Blind randomized controlled trial. American Journal of Psychiatry, 179(2), 132–141. https://doi.org/10.1176/appi.ajp.2021.20101429 [doi]
3. Sackeim, H. A., Aaronson, S. T., Carpenter, L. L., Hutton, T. M., Mina, M., Pages, K., Verdoliva, S., & West, W. S. (2020). Clinical outcomes in a large registry of patients with major depressive disorder treated with Transcranial Magnetic Stimulation. Journal of Affective Disorders, 277, 65–74. https://doi.org/10.1016/j.jad.2020.08.005 [doi]
4. Cash, R. F., Weigand, A., Zalesky, A., Siddiqi, S. H., Downar, J., Fitzgerald, P. B., & Fox, M. D. (2020). Using brain imaging to improve spatial targeting of transcranial magnetic stimulation for depression. Biological Psychiatry, 90(10), 689–700. https://doi.org/10.1016/j.biopsych.2020.05.033 [doi]
5. Downar, J. (2019). Orbitofrontal cortex: a ‘Non-rewarding’ new treatment target in depression? Current Biology, 29(2), R59–R62. https://doi.org/10.1016/j.cub.2018.11.057 [doi]
6. Feffer, K., Fettes, P., Giacobbe, P., Daskalakis, Z. J., Blumberger, D. M., & Downar, J. (2017). 1 Hz rTMS of the right orbitofrontal cortex for major depression: Safety, tolerability and clinical outcomes. European Neuropsychopharmacology, 28(1), 109–117. https://doi.org/10.1016/j.euroneuro.2017.11.011 [doi]
7. Prentice, A., Arns, M., Middleton, V., Bowman, J., Donachie, N., Kriske, J., Kriske, J., Sack, A. T., Downar, J., & Van Der Vinne, N. (2025). Clinical effectiveness of switching to right lateral orbitofrontal cortex-TMS after failure of sequential bilateral dorsolateral prefrontal-TMS in major depression. Transcranial Magnetic Stimulation ., 100190. https://doi.org/10.1016/j.transm.2025.100190 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/364-01-006