Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
605-03-004 ISMRM Abstract

Dynamic Deuterium Metabolic Imaging in Patients with Alzheimer’s Disease at 3T: Initial Feasibility Study

Primary: Neuro - Alzheimer's Disease
Secondary: Contrast Mechanisms - Deuterium
605-03-004 · Next-Generation Neuroimaging for Alzheimer’s Disease: From Molecules to Networks · Thursday, 14 May, 4:00 PM–5:50 PM · Ballroom West
Keywords: Alzheimer's Disease Deuterium Metabolic Imaging Glucose metabolism
Accepted
Yang Fan 1, Jialu Zhang1,2, Jinxia Guo3, Chunsheng Wang4, Rolf F Schulte5, Bing Wu1,6, Feng Chen7,8
1GE Healthcare, Beijing, China
2MR Research, Beijing, China
3GE Healthcare, Beijing 100176, China
4Magtron Inc., Jiangyin, China
5GE Healthcare, Munich, Germany
6GE HealthCare MR Research, Beijing, China
7Hainan General Hospital, and Hainan Medical University Hainan Hospital, China
8Department of Radiology, Hainan General Hospital, and Hainan Medical University Hainan Hospital, China
Presenting Author: Yang Fan

Synopsis

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References

1. Khan AS, Peterson KA, Vittay OI, McLean MA, Kaggie JD, O'Brien JT, Rowe JB, Gallagher FA, Matys T. Deuterium Metabolic Imaging of Alzheimer Disease at 3-T Magnetic Field Strength: A Pilot Case-Control Study. Radiology. 2024 Jul;312(1):e232407. doi: 10.1148/radiol.232407. PMID: 39012255; PMCID: PMC11294762. [doi] [pmid]
2. Bøgh N, Aastrup M, Mortensen JK, Gottrup H, Blicher JU, Borghammer P, Kristensen MH, Hansen ESS, Vaeggemose M, Laustsen C. Comparison of Deuterium Metabolic Imaging with FDG PET in Alzheimer Disease. Radiology. 2025 Apr;315(1):e241808. doi: 10.1148/radiol.241808. PMID: 40197092. [doi] [pmid]
3. Greiser A, von Kienlin M. Efficient k-space sampling by density-weighted phase-encoding. Magn Reson Med. 2003 Dec;50(6):1266-75. doi: 10.1002/mrm.10647. PMID: 14648575. [doi] [pmid]
4. Vanhamme L, van den Boogaart A, Van Huffel S. Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J Magn Reson. 1997 Nov;129(1):35-43. doi: 10.1006/jmre.1997.1244. PMID: 9405214. [doi] [pmid]
5. Xu J, Vaeggemose M, Schulte RF, Yang B, Lee CY, Laustsen C, Magnotta VA. PyAMARES, an Open-Source Python Library for Fitting Magnetic Resonance Spectroscopy Data. Diagnostics (Basel). 2024 Nov 27;14(23):2668. doi: 10.3390/diagnostics14232668. PMID: 39682576; PMCID: PMC11639817. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/605-03-004