Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
465-04-004 ISMRM Abstract

Progressive Glymphatic Impairment Across Alzheimer’s Disease Stages: A Multimodal MRI Study

Primary: Neuro - Alzheimer's Disease
Secondary: Diffusion - DWI/DTI/DKI
465-04-004 · Image Analysis for Alzheimer's and Parkinson's · Tuesday, 12 May, 2:35 PM–3:30 PM · Digital Posters Row F
Keywords: Alzheimer's Disease DTI-ALPS Free-water DTI model Glymphatic system (GS) Perivascular spaces (PVS)
Accepted
Hairong Ma 1, Pu-Yeh Wu2, Songtao Ai1
1Department of Radiology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, China
2GE Healthcare, Beijing, China
Presenting Author: Hairong Ma

Synopsis

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References

1. Scheltens P, De Strooper B, Kivipelto M, et al. Alzheimer's disease. Lancet. 2021;397(10284):1577-1590.
2. Zhang XX, Tian Y, Wang ZT, Ma YH, Tan L, Yu JT. The Epidemiology of Alzheimer's Disease Modifiable Risk Factors and Prevention. J Prev Alzheimers Dis. 2021;8(3):313-321.
3. Iliff JJ et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med. 2012;4(147):147ra111.
4. Xie L, Kang H, Xu Q, et al. Sleep drives metabolite clearance from the adult brain. Science. 2013;342:373-377.
5. Kress BT, Iliff JJ, Xia M, et al. Impairment of paravascular clearance pathways in the aging brain. Ann Neurol. 2014;76:845-861.
6. Kamagata K, Andica C, Takabayashi K, et al. Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease. Neurology. 2022;99(24):e2648-e2660. Published 2022 Dec 12.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/465-04-004