Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
504-04-008 ISMRM Abstract

Effects of brain irradiation on cerebral blood flow, BBB water exchange, vascular integrity, and recognition memory in mice

Primary: Preclinical Animal & in vitro MR - Small Animals
Secondary: Neuro - Blood Vessels
504-04-008 · Cancer Imaging and Spectroscopy · Wednesday, 13 May, 4:00 PM–5:50 PM · Ballroom East
Keywords: Neuroinflammation Cognitive impairment Magnetic Resonance Imaging (MRI) Blood brain barrier Brain Irradiation
Accepted
Annet Nakkazi1, Duncan Forster1,2, Jennifer Fletcher2, Douglas Dyer3,4, Anthony Chalmers5, Kaye Williams2, Ben Dickie1,2,6
1Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester, United Kingdom
2Division of Pharmacy and Optometry, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester, United Kingdom
3Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, UoM, UK, University of Manchester, Manchester, United Kingdom
4Geoffrey Jefferson Brain Research Centre, University of Manchester, University of Manchester, Manchester, United Kingdom
5School of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom
6Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust, The University of Manchester, Manchester, UK., University of Manchester, Manchester, United Kingdom
Presenting Author: Paulina J Villasenor

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References

1. Cramer CK, Cummings TL, Andrews RN, et al. Treatment of Radiation-Induced Cognitive Decline in Adult Brain Tumor Patients. Curr Treat Options Oncol. 2019; 20(5):42. https://pmc.ncbi.nlm.nih.gov/articles/PMC6594685/
2. Armstrong C, Mollman J, Corn BW, Alavi J, Grossman M. Effects of radiation therapy on adult brain behavior: evidence for a rebound phenomenon in a phase 1 trial. Neurology. 1993; 43(10):1961-1965. https://pubmed.ncbi.nlm.nih.gov/8413953/ [pmid]
3. Giovagnoli AR, Boiardi A. Cognitive impairment and quality of life in long-term survivors of malignant brain tumors. Ital J Neurol Sci. 1994; 15(9):481-488. https://pubmed.ncbi.nlm.nih.gov/7721551/ [pmid]
4. Nakkazi A, Forster D, Whitfield GA, Dyer DP, Dickie BR. A systematic review of normal tissue neurovascular unit damage following brain irradiation-Factors affecting damage severity and timing of effects. Neurooncol Adv. 2024; 6(1):vdae098. https://pubmed.ncbi.nlm.nih.gov/39239570/ [pmid]
5. Lou N, Takano T, Pei Y, Xavier AL, Goldman SA, Nedergaard M. Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier. Proc Natl Acad Sci U S A. 2016; 113(4):1074-1079. https://pubmed.ncbi.nlm.nih.gov/26755608/ [pmid]
6. Simmons DA, Lartey FM, Schüler E, et al. Reduced cognitive deficits after FLASH irradiation of whole mouse brain are associated with less hippocampal dendritic spine loss and neuroinflammation. Radiother Oncol. 2019; 139:4-10. https://pubmed.ncbi.nlm.nih.gov/31253467/ [pmid]
7. Zhu L, Ma Y, Kong A, et al. Non-invasive and sensitive MRI assessment of radiation-induced cognitive dysfunction via voxel-based morphological and functional connectivity. Acta Neuropathol Commun. 2025; 13(1):180. https://pubmed.ncbi.nlm.nih.gov/40841911/ [pmid]
8. Alaghband Y, Cheeks SN, Allen BD, et al. Neuroprotection of Radiosensitive Juvenile Mice by Ultra-High Dose Rate FLASH Irradiation. Cancers (Basel). 2020; 12(6). https://pubmed.ncbi.nlm.nih.gov/32599789/ [pmid]
9. Kovács N, Szigeti K, Hegedűs N, et al. Multimodal PET/MRI Imaging Results Enable Monitoring the Side Effects of Radiation Therapy. Contrast Media Mol Imaging. 2018; 2018:5906471. https://pubmed.ncbi.nlm.nih.gov/30515069/ [pmid]
10. Reinhold HS, Hopewell JW. Late changes in the architecture of blood vessels of the rat brain after irradiation. Br J Radiol. 1980; 53(631):693-696. https://pubmed.ncbi.nlm.nih.gov/7426892/ [pmid]
11. Allen BD, Acharya MM, Montay-Gruel P, et al. Maintenance of Tight Junction Integrity in the Absence of Vascular Dilation in the Brain of Mice Exposed to Ultra-High-Dose-Rate FLASH Irradiation. Radiat Res. 2020; 194(6):625-635. https://pubmed.ncbi.nlm.nih.gov/33348373/ [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/504-04-008