Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
369-02-007 ISMRM Abstract

Automated Synthetic Contrast-Enhanced MRI Improves Choroid Plexus Segmentation in Parkinsonian Syndromes.

Primary: Neuro - Parkinson's Disease
Secondary: Analysis Methods - Image Synthesis and Translation
369-02-007 · Imaging Parkinson’s Disease: Multimodal Biomarkers of Progression and Phenotype · Monday, 11 May, 9:15 AM–10:10 AM · Digital Posters Row J
Keywords: Contrast-enhancement Deep learning Synthetic Contrast-enhanced MRI Choroid plexus morphometry Parkinsonian Syndromes
Accepted
Dagnachew T Ambaye 1,2, Huseyin E Candan1,3, Sungyang Jo4, Abel W Tessema1,5, Nepes Myratgeldiyev1, Chong H Suh6, Jihong Ryu4, Sun J Chung4, Hansol Lee1,7, Jae-Hyeok Lee8, Eun-Jae Lee4, HyungJoon Cho1
1Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of
2School of Electrical & Computer Engineering, Hawassa University Institute of Technology, Hawassa, Ethiopia
3Graduate School of Health Science and Technology, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of
4Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of
5School of Biomedical Engineering, Jimma University, Jimma Institute of Technology, Jimma, Ethiopia
6Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of
7Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America
8Department of Neurology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea, Republic of
Presenting Author: Dagnachew T Ambaye

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Hubert V, Chauveau F, Dumot C, et al. Clinical Imaging of Choroid Plexus in Health and in Brain Disorders: A Mini-Review. Front Mol Neurosci. 2019;12:34. doi:10.3389/fnmol.2019.00034. [doi]
2. Xu H, Lotfy P, Gelb S, et al. The choroid plexus synergizes with immune cells during neuroinflammation. Cell. 2024;187(18):4946-4963.e17. doi:10.1016/j.cell.2024.07.002. [doi]
3. Zhou G, Hotta J, Lehtinen MK, Forss N, Hari R. Enlargement of choroid plexus in complex regional pain syndrome. Sci Rep. 2015;5:14329. Published 2015 Sep 21. doi:10.1038/srep14329. [doi]
4. Lublinsky S, Kesler A, Friedman A, Horev A, Shelef I. Quantifying response to intracranial pressure normalization in idiopathic intracranial hypertension via dynamic neuroimaging. J Magn Reson Imaging. 2018;47(4):913-927. doi:10.1002/jmri.25857. [doi]
5. Chaddad A, Desrosiers C, Toews M. Multi-scale radiomic analysis of sub-cortical regions in MRI related to autism, gender and age. Sci Rep. 2017;7:45639. Published 2017 Mar 31. doi:10.1038/srep45639. [doi]
6. Kolahi S, Zarei D, Issaiy M, Shakiba M, Azizi N, Firouznia K. Choroid plexus volume changes in multiple sclerosis: insights from a systematic review and meta-analysis of magnetic resonance imaging studies. Neuroradiology. 2024;66(11):1869-1886. doi:10.1007/s00234-024-03439-3. [doi]
7. Müller J, Sinnecker T, Wendebourg MJ, et al. Choroid Plexus Volume in Multiple Sclerosis vs Neuromyelitis Optica Spectrum Disorder: A Retrospective, Cross-sectional Analysis. Neurol Neuroimmunol Neuroinflamm. 2022;9(3):e1147. doi:10.1212/NXI.0000000000001147. [doi]
8. Ricigliano VAG, Morena E, Colombi A, et al. Choroid Plexus Enlargement in Inflammatory Multiple Sclerosis: 3.0-T MRI and Translocator Protein PET Evaluation. Radiology. 2021;301(1):166-177. doi:10.1148/radiol.2021204426. [doi]
9. Serot JM, Béné MC, Foliguet B, Faure GC. Morphological alterations of the choroid plexus in late-onset Alzheimer's disease. Acta Neuropathol. 2000;99(2):105-108. doi:10.1007/pl00007412. [doi]
10. González-Marrero I, Giménez-Llort L, Johanson CE, et al. Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer's disease. Front Cell Neurosci. 2015;9:17. Published 2015 Feb 6. doi:10.3389/fncel.2015.00017. [doi]
11. Jeong SH, Park CJ, Jeong HJ, et al. Association of choroid plexus volume with motor symptoms and dopaminergic degeneration in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2023;94(12):1047-1055. doi:10.1136/jnnp-2023-331170. [doi]
12. Wang N, Lu J, Liu X, et al. Choroid plexus enlargement correlates with subcortical tau deposition in progressive supranuclear palsy. Fluids Barriers CNS. 2025;22(1):52. Published 2025 May 26. doi:10.1186/s12987-025-00663-8. [doi]
13. Tadayon E, Moret B, Sprugnoli G, et al. Improving Choroid Plexus Segmentation in the Healthy and Diseased Brain: Relevance for Tau-PET Imaging in Dementia. J Alzheimers Dis. 2020;74(4):1057-1068. doi:10.3233/JAD-190706. [doi]
14. Liu L, Weng Q, Cai Q, et al. Choroid plexus enlargement contributes to motor severity via regional glymphatic dysfunction in Parkinson's disease. NPJ Parkinsons Dis. 2025;11(1):134. Published 2025 May 22. doi:10.1038/s41531-025-00971-8. [doi]
15. Okar SV, Fagiani F, Absinta M, Reich DS. Imaging of brain barrier inflammation and brain fluid drainage in human neurological diseases. Cell Mol Life Sci. 2024;81(1):31. Published 2024 Jan 12. doi:10.1007/s00018-023-05073-3. [doi]
16. Solak M, Tören M, Asan B, Kaba E, Beyazal M, Çeliker FB. Generative Adversarial Network-Based Contrast Enhancement: Synthetic Contrast Brain Magnetic Resonance Imaging. Acad Radiol. 2025;32(4):2220-2232. doi:10.1016/j.acra.2024.11.021. [doi]
17. Rohrer M, Bauer H, Mintorovitch J, Requardt M, Weinmann HJ. Comparison of magnetic properties of MRI contrast media solutions at different magnetic field strengths. Invest Radiol. 2005;40(11):715-724. doi:10.1097/01.rli.0000184756.66360.d3. [doi]
18. Kuhl C, Csőszi T, Piskorski W, Miszalski T, Lee JM, Otto PM. Efficacy and Safety of Half-Dose Gadopiclenol versus Full-Dose Gadobutrol for Contrast-enhanced Body.
19. Eisma JJ, McKnight CD, Hett K, et al. Deep learning segmentation of the choroid plexus from structural magnetic resonance imaging (MRI): validation and normative ranges across the adult lifespan. Fluids Barriers CNS. 2024;21(1):21. Published 2024 Feb 29. doi:10.1186/s12987-024-00525-9. [doi]
20. Storelli L, Pagani E, Rubin M, Margoni M, Filippi M, Rocca MA. A Fully Automatic Method to Segment Choroid Plexuses in Multiple Sclerosis Using Conventional MRI Sequences. J Magn Reson Imaging. 2024;59(5):1643-1652. doi:10.1002/jmri.28937. [doi]
21. L. Zhao, X. Feng, C. H. Meyer, and D. C. Alsop, "Choroid Plexus Segmentation Using Optimized 3D U-Net," 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI), Iowa City, IA, USA, 2020, pp. 381-384, doi: 10.1109/ISBI45749.2020.9098443. [doi]
22. Yazdan-Panah A, Schmidt-Mengin M, Ricigliano VAG, Soulier T, Stankoff B, Colliot O. Automatic segmentation of the choroid plexuses: Method and validation in controls and patients with multiple sclerosis. Neuroimage Clin. 2023;38:103368. doi:10.1016/j.nicl.2023.103368. [doi]
23. Ambaye DT, Tessema AW, Jeong J, et al. Resolution-dependent MRI-to-CT translation for orthotopic breast cancer models using deep learning. Phys Med Biol. 2024;69(23):10.1088/1361-6560/ad9076. Published 2024 Nov 21. doi:10.1088/1361-6560/ad9076. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/369-02-007