Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
463-03-001 ISMRM Abstract

Multi-echo fMRI improves breath-hold BOLD cerebrovascular reactivity estimates in stroke

Primary: Brain Function and fMRI - fMRI Analysis
Secondary: Neuro - Stroke and Cerebrovascular Disorders
463-03-001 · Metabolic Parameters in Stroke · Tuesday, 12 May, 1:40 PM–2:35 PM · Digital Posters Row D
Keywords: Cerebrovascular reactivity Denoising Fmri Breath-hold Multi-Echo
Accepted
Rebecca G Clements 1,2, Fatemeh Geranmayeh3,4, Niamh V Parkinson3,4, Molly Bright1,2
1Biomedical Engineering, Northwestern University, Chicago, United States of America
2Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, United States of America
3Department of Brain Sciences, Imperial College, London, United Kingdom
4NHS Trust, Imperial College Healthcare, United Kingdom
Presenting Author: Rebecca G Clements

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References

1. van Niftrik CHB, Sebök M, Germans MR, et al. Increased Risk of Recurrent Stroke in Symptomatic Large Vessel Disease With Impaired BOLD Cerebrovascular Reactivity. Stroke. 2024;55(3):613-621. doi:10.1161/strokeaha.123.044259 [doi]
2. Geranmayeh F, Wise RJS, Leech R, Murphy K. Measuring vascular reactivity with breath-holds after stroke: A method to aid interpretation of group-level BOLD signal changes in longitudinal fMRI studies. Hum Brain Mapp. 2015;36(5):1755-1771. doi:10.1002/HBM.22735 [doi]
3. Krishnamurthy V, Sprick JD, Krishnamurthy LC, et al. The Utility of Cerebrovascular Reactivity MRI in Brain Rehabilitation: A Mechanistic Perspective. Front Physiol. 2021;12(2):642850. 2021;12(2):642850. doi:10.3389/FPHYS.2021.642850 [doi]
4. Seto E, Sela G, McIlroy WE, et al. Quantifying Head Motion Associated with Motor Tasks Used in fMRI. Neuroimage. 2001;14(2):284-297. doi:10.1006/NIMG.2001.0829 [doi]
5. Mandell DM, Han JS, Poublanc J, et al. Quantitative measurement of cerebrovascular reactivity by blood oxygen level-dependent MR imaging in patients with intracranial stenosis: preoperative cerebrovascular reactivity predicts the effect of extracranial-intracranial bypass surgery. AJNR Am J Neuroradiol. 2011;32(4):721-727. doi:10.3174/ajnr.A2365 [doi]
6. DuPre E, Salo T, Ahmed Z, et al. TE-dependent analysis of multi-echo fMRI with *tedana*. J Open Source Softw. 2021;6(66):3669. doi:10.21105/JOSS.03669 [doi]
7. Moia S, Termenon M, Uruñuela E, et al. ICA-based denoising strategies in breath-hold induced cerebrovascular reactivity mapping with multi echo BOLD fMRI. Neuroimage. 2021;233:117914. doi:10.1016/J.NEUROIMAGE.2021.117914 [doi]
8. Reddy NA, Zvolanek KM, Moia S, Caballero-Gaudes C, Bright MG. Denoising task-correlated head motion from motor-task fMRI data with multi-echo ICA. Imaging Neuroscience. 2024;2:1-30. doi:10.1162/IMAG_A_00057 [doi]
9. Zvolanek KM, Moia S, Dean JN, Stickland RC, Caballero-Gaudes C, Bright MG. Comparing end-tidal CO2, respiration volume per time (RVT), and average gray matter signal for mapping cerebrovascular reactivity amplitude and delay with breath-hold task BOLD fMRI. Neuroimage. 2023;272:120038. doi:10.1016/J.NEUROIMAGE.2023.120038 [doi]
10. Moia S, Vigotsky AD, Zvolanek KM. phys2cvr: A tool to compute Cerebrovascular Reactivity maps and associated lag maps. Zenodo. 2025;0.19.0. doi:10.5281/ZENODO.7336002 [doi]
11. Schmal C, Myung J, Herzel H, Bordyugov G. Moran’s I quantifies spatio-temporal pattern formation in neural imaging data. Bioinformatics. 2017;33(19):3072-3079. doi:10.1093/BIOINFORMATICS/BTX351 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/463-03-001