Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
469-05-003 ISMRM Abstract

Variability in 13C MRS measurement of Leg Glycogen in Children.

Primary: Contrast Mechanisms - Non-Proton
Secondary: Body - Liver
469-05-003 · Non-Proton MRI: Methods and Applications · Tuesday, 12 May, 4:00 PM–4:55 PM · Digital Posters Row J
Keywords: Liver Glycogen 13C Peadiatric
Accepted
Abi Spicer1,2, Elizabeth J Simpson3,4, Ian Macdonald4, Penny Gowland2,4, Stephen Bawden 1,2,4,5,6
1Nottingham Digestive Diseases Centre, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom
2Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom
3David Greenfield Human Physiology Unit, MRC/ARUK Centre for Musculoskeletal Ageing Research, University of Nottingham, Nottingham, United Kingdom
4NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom
5Department of Medical Physics and Clinical Engineering, Swansea Bay University Health Board, Swansea, United Kingdom
6Institute of Life Sciences, Medical School, Swansea University, Swansea, United Kingdom
Presenting Author: Stephen Bawden

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References

1. Taylor R, Price TB, Rothman DL, Shulman RG, Shulman GI. Validation of 13C NMR measurement of human skeletal muscle glycogen by direct biochemical assay of needle biopsy samples. Magn Reson Med [Internet]. 1992 [cited 2022 Jul 25];27(1):13–20. Available from: https://pubmed.ncbi.nlm.nih.gov/1435198/ [pmid]
2. Eriksson BO, Gollnick PD, Saltin B. Muscle Metabolism and Enzyme Activities after Training in Boys 11–13 Years Old. Acta Physiol Scand. 1973;87(4):485–97.
3. Horstman AM, Bawden SJ, Spicer A, Darwish N, Goyer A, Egli L, et al. Liver glycogen stores via 13C magnetic resonance spectroscopy in healthy children: randomized, controlled study. Am J Clin Nutr. 2023 Apr 1;117(4):709–16.
4. Buehler T, Bally L, Dokumaci AS, Stettler C, Boesch C. Methodological and physiological test–retest reliability of 13C-MRS glycogen measurements in liver and in skeletal muscle of patients with type 1 diabetes and matched healthy controls. NMR Biomed [Internet]. 2016 Jun 1 [cited 2023 Dec 13];29(6):796–805. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/nbm.3531
5. Stephenson MC, Leverton E, Khoo EYH, Poucher SM, Johansson L, Lockton JA, et al. Variability in fasting lipid and glycogen contents in hepatic and skeletal muscle tissue in subjects with and without type 2 diabetes: a 1H and 13C MRS study. NMR Biomed [Internet]. 2013 Nov 1 [cited 2023 Dec 13];26(11):1518–26. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/nbm.2985

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http://echo.ismrm.org/p/ISMRM2026/469-05-003