Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
362-06-001 ISMRM Abstract

Characterizing the relationship between cerebral perfusion and amyloid PET Centiloids in Alzheimer’s disease

Primary: Neuro - Alzheimer's Disease
Secondary: Neuro - Dementia
362-06-001 · Neuroimaging Biomarkers of Aging, Vascular Health, and Dementia · Monday, 11 May, 5:05 PM–6:00 PM · Digital Posters Row C
Keywords: Alzheimer's Disease Perfusion Amyloid PET Arterial Spin Labelling (ASL)
Accepted
Yufei D Zhu1, Qinyang Shou1, Xinhui Wang2, Arthur W Toga1, Vasilis Z Marmarelis3, Meredith Braskie1,2, Helena Chui2, Danny J Wang 1,2
1USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, United States of America
2Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, United States of America
3Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, United States of America
Presenting Author: Danny J Wang

Synopsis

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References

1. Kim, G.H., et al., Elevated cerebral blood flow proxy with increased beta-amyloid burden in Alzheimer's disease preclinical phase evaluated by dual-phase (18)F-florbetaben positron emission tomography. Sci Rep, 2024. 14(1): p. 18480. DOI: 10.1038/s41598-024-68916-4. [doi]
2. Zhang, H., et al., Cerebral blood flow in mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis. Ageing Res Rev, 2021. 71: p. 101450. DOI: 10.1016/j.arr.2021.101450. [doi]
3. Swinford, C.G., et al., Altered cerebral blood flow in older adults with Alzheimer's disease: a systematic review. Brain Imaging Behav, 2023. 17(2): p. 223–256. DOI: 10.1007/s11682-022-00750-6. [doi]
4. Swinford, C.G., et al., Amyloid and tau pathology are associated with cerebral blood flow in a mixed sample of nondemented older adults with and without vascular risk factors for Alzheimer's disease. Neurobiol Aging, 2023. 130: p. 103–113. DOI: 10.1016/j.neurobiolaging.2023.06.014. [doi]
5. Rubinski, A., et al., Lower cerebral perfusion is associated with tau-PET in the entorhinal cortex across the Alzheimer's continuum. Neurobiol Aging, 2021. 102: p. 111–118. DOI: 10.1016/j.neurobiolaging.2021.02.003. [doi]
6. Taghvaei, M., et al., Regional cerebral blood flow reflects both neurodegeneration and microvascular integrity across the Alzheimer's continuum. Alzheimers Dement, 2025. 21(1): p. e14382. DOI: 10.1002/alz.14382. [doi]
7. Shou, Q., et al., Diffusion model enables quantitative CBF analysis of Alzheimer's Disease. medRxiv, 2024. DOI: 10.1101/2024.07.01.24309791. [doi]
8. Royse, S.K., et al., Validation of amyloid PET positivity thresholds in centiloids: a multisite PET study approach. Alzheimers Res Ther, 2021. 13(1): p. 99. DOI: 10.1186/s13195-021-00836-1. [doi]
9. Ricaurte-Fajardo, A., et al., Anti-amyloid therapy and cerebral blood flow changes on Magnetic Resonance Imaging: a potential longitudinal biomarker of treatment response? AJNR Am J Neuroradiol, 2025. DOI: 10.3174/ajnr.A8654 [doi]

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http://echo.ismrm.org/p/ISMRM2026/362-06-001