Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
470-09-143 ISMRM Abstract

Mild COVID-19 Is Associated with Microstructural Brain Changes from Pre-Pandemic Baseline in Healthy Young Adults.

Primary: Neuro - Infectious Disease
Secondary: Diffusion - Microstructure
470-09-143 · MRI in Infectious Diseases · Tuesday, 12 May, 4:00 PM–4:55 PM · Traditional Posters | Exhibition Hall
Keywords: COVID-19 Magnetic Resonance Imaging (MRI) Cognitive Function Diffusion Tensor Imaging (DTI) White matter microstructure
Accepted
Luca Bremner1, Roman Fleysher 1, Kenny Ye2, Katherine H Ho1, Molly E Zimmerman3, Mimi Kim2, Shalika Fnu4, Ariana Olivares1, Richard B Lipton2,5, Johanna P Daily4,6, Michael L Lipton1,7
1Department of Radiology, Columbia University Irving Medical Center, New York, United States of America
2Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, United States of America
3Department of Psychology, Fordham University, New York, United States of America
4Department of Medicine (Infectious Disease), Albert Einstein College of Medicine, Bronx, United States of America
5Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, United States of America
6Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, United States of America
7Department of Biomedical Engineering, Columbia University, New York, United States of America
Presenting Author: Roman Fleysher

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References

1. Ceban F, Ling S, Lui LMW, et al. Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis. Brain Behav Immun. 2022;101:93-135. doi:10.1016/j.bbi.2021.12.020 [doi]
2. Nelson BK, Farah LN, Saint SA, et al. Diffusion tensor imaging after COVID-19 infection: A systematic review. Neuroimage. 2025;310:121150. doi:10.1016/j.neuroimage.2025.121150 [doi]
3. Douaud G, Lee S, Alfaro-Almagro F, et al. SARS-CoV-2 is associated with changes in brain structure in UK Biobank. Nature. 2022;604(7907):697-707. doi:10.1038/s41586-022-04569-5 [doi]
4. Hutchinson EB, Schwerin SC, Avram AV, Juliano SL, Pierpaoli C. Diffusion MRI and the detection of alterations following traumatic brain injury. J Neurosci Res. 2018;96(4):612-625. doi:10.1002/jnr.24065 [doi]
5. Zhuo J, Xu S, Proctor JL, et al. Diffusion kurtosis as an in vivo imaging marker for reactive astrogliosis in traumatic brain injury. Neuroimage. 2012;59(1):467-477. doi:10.1016/j.neuroimage.2011.07.050 [doi]
6. Schwabenland M, Salié H, Tanevski J, et al. Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions. Immunity. 2021;54(7):1594-1610.e11. doi:10.1016/j.immuni.2021.06.002 [doi]

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http://echo.ismrm.org/p/ISMRM2026/470-09-143