Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
567-06-005 ISMRM Abstract

A Novel Approach for Optimization of MEGA-sLASER for Profiling of IDH-mutated Gliomas using in vivo 1H-MR Spectroscopy at 3T

Primary: Contrast Mechanisms - Spectroscopy
Secondary: Neuro - Tumors
567-06-005 · Novel Contrast Mechanisms II · Wednesday, 13 May, 4:55 PM–5:50 PM · Digital Posters Row H
Keywords: Glioma MRS MR spectroscopy Neurometabolites MRI sequence optimization
Accepted
Ronald Instrella 1, Russell D Posner2, Karl Landheer3, Fabio Iwamoto4, Sachin Jambawalikar1,5, Christoph Juchem6, Angela Lignelli2
1Biomedical Engineering, Columbia University, New York, United States of America
2Radiology, Columbia University Irving Medical Center, New York, United States of America
3Regeneron Genetics Center, LLC, Tarrytown, United States of America
4Neurology, Columbia University Irving Medical Center, New York, United States of America
5Radiology, Columbia University Vagelos College of Physicians and Surgeons, New York, United States of America
6Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
Presenting Author: Ronald Instrella

Synopsis

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References

1. Andronesi OC, Rapalino O, Gerstner E, et al. Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate. J Clin Invest. 2013;123(9):3659-3663. doi:10.1172/JCI67229 [doi]
2. Dang L, White DW, Gross S, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009;462(7274):739-744. doi:10.1038/nature08617 [doi]
3. Mescher M, Merkle H, Kirsch J, Garwood M, Gruetter R. Simultaneous in vivo spectral editing and water suppression. NMR Biomed. 1998;11(6):266-272. doi:10.1002/(SICI)1099-1492(199810)11:6<266::AID-NBM530>3.0.CO;2-J [doi]
4. Scheenen TWJ, Heerschap A, Klomp DWJ. Towards 1H-MRSI of the human brain at 7T with slice-selective adiabatic refocusing pulses. Magn Reson Mater Phys Biol Med. 2008;21(1-2):95-101. doi:10.1007/s10334-007-0094-y [doi]
5. Choi C, Ganji SK, DeBerardinis RJ, et al. 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas. Nat Med. 2012;18(4):624-629. doi:10.1038/nm.2682 [doi]
6. Berrington A, Voets NL, Plaha P, et al. Improved Localization for 2-Hydroxyglutarate Detection at 3 T Using Long-TE Semi-LASER. Tomography. 2016;2(2):94-105. doi:10.18383/j.tom.2016.00139 [doi]
7. Chan KL, Hapani R, Maher EA, Patel TR, Henning A. TE optimization for J‐difference editing of 2‐hydroxyglutarate at 3T. Magn Reson Med. 2025;94(4):1363-1376. doi:10.1002/mrm.30561 [doi]
8. Landheer K, Swanberg KM, Juchem C. Magnetic resonance Spectrum simulator (MARSS), a novel software package for fast and computationally efficient basis set simulation. NMR Biomed. 2021;34(5). doi:10.1002/nbm.4129 [doi]
9. Gajdošík M, Landheer K, Swanberg KM, Juchem C. INSPECTOR: free software for magnetic resonance spectroscopy data inspection, processing, simulation and analysis. Sci Rep. 2021;11(1):2094. doi:10.1038/s41598-021-81193-9 [doi]
10. Cavassila S, Deval S, Huegen C, van Ormondt D, Graveron-Demilly D. Cramér-Rao bounds: an evaluation tool for quantitation. NMR Biomed. 2001;14(4):278-283. doi:10.1002/nbm.701 [doi]
11. Kreis R. The trouble with quality filtering based on relative Cramér-Rao lower bounds. Magn Reson Med. 2016;75(1):15-18. doi:10.1002/mrm.25568 [doi]
12. Instrella R, Juchem C. Uncertainty propagation in absolute metabolite quantification for in vivo MRS of the human brain. Magn Reson Med. 2024;91(4):1284-1300. doi:10.1002/mrm.29903 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/567-06-005