Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
362-02-001 ISMRM Abstract

Reversible White Matter Microstructural Changes in Hyperthyroidism: A Diffusion Kurtosis Imaging

Primary: Diffusion - DWI/DTI/DKI
Secondary: Diffusion - Microstructure
362-02-001 · Clinical Diffusion Neuro · Monday, 11 May, 9:15 AM–10:10 AM · Digital Posters Row C
Keywords: Diffusion kurtosis imaging White matter tracts Microstructural alterations Hyperthyroidism Thyroxine
Accepted
Mukesh Kumar1,2, Pankaj Pankaj 3, Arman Deep Singh1, PAWAN KUMAR2, Poonam Rana2, Tarun Sekhri2, Maria D’souza2, Subash Khushu1
1The University of Trans-Disciplinary Health Sciences and Technology, Bengaluru, India
2Institute of Nuclear Medicine and Allied Sciences, Delhi, India
3All India Institute of Medical Sciences, New Delhi, India
Presenting Author: Pankaj Pankaj

Synopsis

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References

1. 1. Bernal, J., Guadaño-Ferraz, A. & Morte, B. Perspectives in the study of thyroid hormone action on brain development and function. Thyroid Off. J. Am. Thyroid Assoc. 13, 1005–1012 (2003).
2. 2. Calzà, L., Fernández, M. & Giardino, L. Role of the Thyroid System in Myelination and Neural Connectivity. Compr. Physiol. 5, 1405–1421 (2015).
3. 3. Chaker, L. et al. Age-dependent association of thyroid function with brain morphology and microstructural organization: evidence from brain imaging. Neurobiol. Aging 61, 44–51 (2018).
4. 4. Wu, Q. et al. Morphological and microstructural brain changes in thyroid-associated ophthalmopathy: a combined voxel-based morphometry and diffusion tensor imaging study. J. Endocrinol. Invest. 43, 1591–1598 (2020).
5. 5. Wu, Q. et al. Disrupted Topological Organization of the Brain Structural Network in Patients With Thyroid-Associated Ophthalmopathy. Invest. Ophthalmol. Vis. Sci. 62, 5 (2021).
6. 6. Pershad, D. & Verma, S. K. Handbook of PGI Battery of Brain Dysfunction (PGI-BBD) Agra (IN): National Psychological Corporation; 1990. Google Sch. 172 (1990).
7. 7. Zhu, J. et al. Performances of diffusion kurtosis imaging and diffusion tensor imaging in detecting white matter abnormality in schizophrenia. NeuroImage Clin. 7, 170–176 (2015).
8. 8. Baud, O. et al. Nitric oxide-induced cell death in developing oligodendrocytes is associated with mitochondrial dysfunction and apoptosis-inducing factor translocation. Eur. J. Neurosci. 20, 1713–1726 (2004).

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http://echo.ismrm.org/p/ISMRM2026/362-02-001