Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
369-03-001 ISMRM Abstract

Lateralized Neurovascular-Glymphatic Imbalance and Cognitive Heterogeneity in Mild Ischemic Stroke: A Multimodal MRI Study

Primary: Neuro - Stroke and Cerebrovascular Disorders
Secondary: Body - Body Composition
369-03-001 · Multiparametric MRI in Stroke · Monday, 11 May, 1:50 PM–2:45 PM · Digital Posters Row J
Keywords: Cognitive impairments Glymphatic system Mild ischemic stroke Intracranial atherosclerotic stenosis
Accepted
Xiaotong Chi1, Wanghuan Dun1, Ming Zhang2, Jianfeng Han3, Meiling Shang4, Huiping Liu 4, Yanran Chen4, Chiyin Li4, Gezhi Yan3, Bingbing Guo3, Yi Zhu5,6, Guangxu Han7
1The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
2the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, Xi'an, China
3Department of Neurology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, Xi'an, China
4School of Future Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, China
5Clinical and Technical Support, Philips Healthcare (Xi'an), Xi'an, China
6Department of Clinical & Technical Support, Clinical and Technical Support, Philips Healthcare (Xi'an), Xi'an, China
7GE HealthCare MR Research, Beijing, China
Presenting Author: Huiping Liu

Synopsis

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References

1. Pendlebury ST, Rothwell PM, Oxford Vascular S. Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study. Lancet Neurol. Mar 2019;18(3):248-258. doi:10.1016/S1474-4422(18)30442-3 [doi]
2. Taoka T, Masutani Y, Kawai H, et al. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases. Jpn J Radiol. Apr 2017;35(4):172-178. doi:10.1007/s11604-017-0617-z [doi]
3. Wu J, Xia Y, Wang X, et al. uRP: An integrated research platform for one-stop analysis of medical images. Front Radiol. 2023;3:1153784. doi:10.3389/fradi.2023.1153784 [doi]
4. Fultz NE, Bonmassar G, Setsompop K, et al. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep. Science. Nov 1 2019;366(6465):628-631. doi:10.1126/science.aax5440 [doi]
5. Chen Y, Lin L, Bhuiyan MIH, et al. Transient ischemic stroke triggers sustained damage of the choroid plexus blood-CSF barrier. Front Cell Neurosci. 2023;17:1279385. doi:10.3389/fncel.2023.1279385 [doi]
6. Iliff JJ, Wang M, Liao Y, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med. Aug 15 2012;4(147):147ra111. doi:10.1126/scitranslmed.3003748 [doi]
7. Passiak BS, Liu D, Kresge HA, et al. Perivascular spaces contribute to cognition beyond other small vessel disease markers. Neurology. Mar 19 2019;92(12):e1309-e1321. doi:10.1212/WNL.0000000000007124 [doi]
8. Coupland KG, Amell MF, Spratt NJ. Brain fluid physiology in ischaemic stroke; more than just oedema. Fluids Barriers CNS. Jun 18 2025;22(1):60. doi:10.1186/s12987-025-00671-8 [doi]
9. Woods DL, Kishiyamaa MM, Lund EW, et al. Improving digit span assessment of short-term verbal memory. J Clin Exp Neuropsychol. Jan 2011;33(1):101-11. doi:10.1080/13803395.2010.493149 [doi]
10. Llinas-Regla J, Vilalta-Franch J, Lopez-Pousa S, Calvo-Perxas L, Torrents Rodas D, Garre-Olmo J. The Trail Making Test. Assessment. Mar 2017;24(2):183-196. doi:10.1177/1073191115602552 [doi]
11. Ke Z, Mo Y, Li J, et al. Glymphatic Dysfunction Mediates the Influence of White Matter Hyperintensities on Episodic Memory in Cerebral Small Vessel Disease. Brain Sci. Nov 24 2022;12(12)doi:10.3390/brainsci12121611 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/369-03-001