Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
461-04-002 ISMRM Abstract

Time-Dependent Diffusion MRI for Noninvasive Evaluation of the Immune Microenvironment in Cervical Cancer

Primary: Diffusion - Microstructure
Secondary: Body - Uterus
461-04-002 · Quantitative MRI Across the Body · Tuesday, 12 May, 2:35 PM–3:30 PM · Digital Posters Row B
Keywords: Cervical cancer Td-dMRI Tumor immune microenvironment
Accepted
Wei Wang 1, Wenchao Wang2, Xiaoming Liu3,4, Thorsten Feiweier5,6,7,8,9,10,11,12,13, Yueluan jiang14, Mengchao Zhang1
1Department of Radiology, China-Japan Union Hospital of Jilin University, Changchun, China
2China-Japan Union Hospital of Jilin University, Changchun, China
3MR Research Collaboration, Siemens Healthineers Ltd., Beijing, China
4Research Collaboration Team, Siemens Healthineers, Beijing, China
5Siemens Healthineers AG, Erlangen, Germany
6Siemens Healthineers AG, Forchheim, Germany
7Siemens Healthcare GmbH, Erlangen, Germany
8Neurology Applications Development, Siemens Healthcare GmbH, Erlangen, Germany
9MR Research and Clinical Translation, Siemens Healthineers AG, Erlangen, Germany
10MR Research & Clinical Translation, Erlangen, Germany
11Research & Clinical Translation, Magnetic Resonance, Siemens Healthineers AG, Erlangen, Germany
12MR Research & Clinical Translation, Siemens Healthineers AG, Erlangen, Germany
13MR Application Predevelopment, Siemens Healthineers AG, Forchheim, Germany
14MR Research Collaboration, Shanghai, China
Presenting Author: Wei Wang

Synopsis

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References

1. Monk BJ, Colombo N, Tewari KS, Dubot C, Caceres MV, Hasegawa K, Shapira- Frommer R, Salman P, Yañez E, Gümüş M, Olivera Hurtado de Mendoza M, Samouëlian V, Castonguay V, Arkhipov A, Tekin C, Li K, Keefe SM, Lorusso D; KEYNOTE-826 Investigators. First-Line Pembrolizumab + Chemotherapy Versus Placebo + Chemotherapy for Persistent, Recurrent, or Metastatic Cervical Cancer: Final Overall Survival Results of KEYNOTE-826. J Clin Oncol. 2023 Dec 20;41(36):5505-5511. doi: 10.1200/JCO.23.00914. [doi]
2. Gorvel L, Panouillot M, Rouvière MS, Billon E, Fattori S, Sonongbua J, Boucherit N, Ben Amara A, Quilichini O, Granjeaud S, Degos C, Nunès JA, Carcopino X, Lambaudie E, Chrétien AS, Sabatier R, Dieu-Nosjean MC, Olive D. Tertiary Lymphoid Structures Are Associated with Enhanced Macrophage Activation and Immune Checkpoint Expression and Predict Outcome in Cervical Cancer. Cancer Immunol Res. 2025 May 2;13(5):712-728. doi: 10.1158/2326-6066. [doi]
3. Fan J, Lu F, Qin T, Peng W, Zhuang X, Li Y, Hou X, Fang Z, Yang Y, Guo E, Yang B, Li X, Fu Y, Kang X, Wu Z, Han L, Mills GB, Ma X, Li K, Wu P, Ma D, Chen G, Sun C. Multiomic analysis of cervical squamous cell carcinoma identifies cellular ecosystems with biological and clinical relevance. Nat Genet. 2023 Dec;55(12):2175-2188. doi: 10.1038/s41588-023-01570-0. [doi]
4. Hoffmann E, Gerwing M, Niland S, Niehoff R, Masthoff M, Geyer C, Wachsmuth L, Wilken E, Höltke C, Heindel WL, Hoerr V, Schinner R, Berger P, Vogl T, Eble JA, Maus B, Helfen A, Wildgruber M, Faber C. Profiling specific cell populations within the inflammatory tumor microenvironment by oscillating-gradient diffusion-weighted MRI. J Immunother Cancer. 2023 Mar;11(3):e006092. doi: 10.1136/jitc-2022-006092. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/461-04-002