504-04-003 ISMRM Abstract

Deuterium MR Spectroscopy of tumor models to examine their balance in glycolytic and oxidative metabolism

Primary: Preclinical Animal & in vitro MR - Biology, Models, Methods

Secondary: Preclinical Animal & in vitro MR - Biomarkers

504-04-003 · Cancer Imaging and Spectroscopy · Wednesday, 13 May, 4:00 PM–5:50 PM · Ballroom East

Keywords: Deuterium Metabolic Imaging Tumor microenvironment Deuterium MRSI Deuterium-labeled glucose Glycolysis

Accepted

Andor Veltien ¹, Jack van Asten¹, Eva Berkhout¹, Sandra Heskamp¹, Daan Boreel¹, Arend Heerschap¹

¹Department of Medical Imaging, Radboud University Medical Center, Nijmegen, Netherlands

Presenting Author: Andor Veltien

Synopsis

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References

1. Boreel, et al. (2024) “Inhibition of OXPHOS induces metabolic rewiring and reduces hypoxia in murine tumor models” Clin Transl Radiat Oncol. 49:100875. DOI:10.1016/j.ctro.2024.100875 [doi]

2. Lu, et al. (2017). "Quantitative assessment of brain glucose metabolic rates using in vivo deuterium magnetic resonance spectroscopy." J Cereb Blood Flow Metab 37(11): 3518-3530. DOI:10.1177/0271678X17706444 [doi]

3. De Feyter, et al. (2018). "Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo." Sci Adv 4(8): eaat7314. DOI:10.1126/sciadv.aat7314 [doi]

4. https://medicine.yale.edu/lab/dmi/

5. Vanhamme, et al. (1997). "Improved method for accurate and efficient quantification of MRS data with use of prior knowledge." J Magn Reson 129(1): 35-43. DOI:0.1006/jmre.1997.1244.

6. Kreis, et al. (2020). “Measuring Tumor Glycolytic Flux in Vivo by Using Fast Deuterium MRI” Radiology 2020 Feb;294(2):289-296. DOI:10.1148/radiol.2019191242 [doi]

7. Simões, et al. (2022). “Glucose fluxes in glycolytic and oxidative pathways detected in vivo by deuterium magnetic resonance spectroscopy reflect proliferation in mouse glioblastoma” Neuroimage Clin. 2022:33:102932. DOI:10.1016/j.nicl.2021.102932 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/504-04-003