Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
460-05-006 ISMRM Abstract

Glymphatic Impairment: a potential early mechanism in glioma-related epilepsy

Primary: Diffusion - Diffusion Analysis & Visualization
Secondary: Neuro - Epilepsy
460-05-006 · When Brain Clearance Fails: Glymphatic Dysfunction Across Disorders · Tuesday, 12 May, 4:00 PM–4:55 PM · Digital Posters Row A
Accepted
Ting Chen 1, Xiaoyue Ma2, MENGZHU WANG3, Li Kaixin3, Yong Zhang1
1Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
2The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
3MR Collaborations, Beijing, China
Presenting Author: Ting Chen

Synopsis

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References

1. Liang S, Fan X, Zhao M, Shan X, Li W, Ding P, You G, Hong Z, Yang X, Luan G et al: Clinical practice guidelines for the diagnosis and treatment of adult diffuse glioma-related epilepsy. Cancer Med 2019, 8(10):4527-4535.
2. Shin JY, Kizilbash SH, Robinson SI, Uhm JH, Hammack JE, Lachance DH, Buckner JC, Jatoi A: Seizures in patients with primary brain tumors: what is their psychosocial impact? J Neurooncol 2016, 128(2):285-291.
3. Deleo F, Thom M, Concha L, Bernasconi A, Bernhardt BC, Bernasconi N: Histological and MRI markers of white matter damage in focal epilepsy. Epilepsy Res 2018, 140:29-38.
4. Klostranec JM, Vucevic D, Bhatia KD, Kortman HGJ, Krings T, Murphy KP, terBrugge KG, Mikulis DJ: Current Concepts in Intracranial Interstitial Fluid Transport and the Glymphatic System: Part I-Anatomy and Physiology. Radiology 2021, 301(3):502-514.
5. Zhang S, Zhao F, Yang X, Tan Q, Li S, Shao H, Su X, Gong Q, Yue Q: Multiparametric mapping of white matter reorganizations in patients with frontal glioma-related epilepsy. CNS Neurosci Ther 2023, 29(8):2366-2376.
6. Xu D, Zhou J, Mei H, Li H, Sun W, Xu H: Impediment of Cerebrospinal Fluid Drainage Through Glymphatic System in Glioma. Front Oncol 2021, 11:790821.
7. Lohela TJ, Lilius TO, Nedergaard M: The glymphatic system: implications for drugs for central nervous system diseases. Nat Rev Drug Discov 2022, 21(10):763-779.
8. Kipnis J: Multifaceted interactions between adaptive immunity and the central nervous system. Science 2016, 353(6301):766-771.
9. Rempe RG, Hartz AMS, Soldner ELB, Sokola BS, Alluri SR, Abner EL, Kryscio RJ, Pekcec A, Schlichtiger J, Bauer B: Matrix
10. Marchi N, Granata T, Ghosh C, Janigro D: Blood-brain barrier dysfunction and epilepsy: pathophysiologic role and therapeutic approaches. Epilepsia 2012, 53(11):1877-1886.
11. Gao A, Zhang H, Yan X, Wang S, Chen Q, Gao E, Qi J, Bai J, Zhang Y, Cheng J: Whole-Tumor Histogram Analysis of Multiple Diffusion Metrics for Glioma Genotyping. Radiology 2022, 302(3):E16.
12. Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G et al: The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol 2021, 23(8):1231-1251.
13. Jiang T, Nam DH, Ram Z, Poon WS, Wang J, Boldbaatar D, Mao Y, Ma W, Mao Q, You Y et al: Clinical practice guidelines for the management of adult diffuse gliomas. Cancer Lett 2021, 499:60-72.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/460-05-006