Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
565-01-005 ISMRM Abstract

Glymphatic Dysfunction in Multiple Sclerosis and its Association with Brain Structural Damage and Cognitive Impairment

Primary: Neuro - Neuroinflammation
Secondary: Neuro - Multiple Sclerosis
565-01-005 · Neuroinflammation: Fluids and Flow · Wednesday, 13 May, 8:20 AM–9:15 AM · Digital Posters Row F
Accepted
Zhuo Wang1, Kai AI2, Peng Wu3, Jing Zhang 4
1Department of Magnetic Resonance, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China
2Department of Clinical and Technical Support, Philips Healthcare (Xi'an), Xi'an, China
3Clinical and Technical Support, Philips Healthcare (Beijing), Beijing, China
4The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China
Presenting Author: Jing Zhang

Synopsis

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References

1. 1、Benedict, R.H.B., Amato, M.P., DeLuca, J., Geurts, J.J.G., 2020. Cognitive impairment in multiple sclerosis: clinical management, MRI, and therapeutic avenues. Lancet Neurol 19, 860-871.
2. 2、Iliff, J.J., Wang, M., Liao, Y., Plogg, B.A., Peng, W., Gundersen, G.A., Benveniste, H., Vates, G.E., Deane, R., Goldman, S.A., Nagelhus, E.A., Nedergaard, M., 2012. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med 4, 147ra111.
3. 3、Klostranec, J.M., Vucevic, D., Bhatia, K.D., Kortman, H.G.J., Krings, T., Murphy, K.P., terBrugge, K.G., Mikulis, D.J., 2021. Current Concepts in Intracranial Interstitial Fluid Transport and the Glymphatic System: Part I-Anatomy and Physiology. Radiology 301, 502-514.
4. 4、Preziosa, P., Pagani, E., Meani, A., Storelli, L., Margoni, M., Yudin, Y., Tedone, N., Biondi, D., Rubin, M., Rocca, M.A., Filippi, M., 2024. Chronic active lesions and larger choroid plexus explain cognition and fatigue in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 11, e200205.
5. Amato, M.P., Morra, V.B., Falautano, M., Ghezzi, A., Goretti, B., Patti, F., Riccardi, A., Mattioli, F., 2018. Cognitive assessment in multiple sclerosis-an Italian consensus. Neurol Sci 39, 1317-1324.
6. Eisma, J.J., McKnight, C.D., Hett, K., Elenberger, J., Han, C.J., Song, A.K., Considine, C., Claassen, D.O., Donahue, M.J., 2024. Deep learning segmentation of the choroid plexus from structural magnetic resonance imaging (MRI): validation and normative ranges across the adult lifespan. Fluids Barriers CNS 21, 21.

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http://echo.ismrm.org/p/ISMRM2026/565-01-005