Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
504-04-010 ISMRM Abstract

MRI/MRS Measures of Therapeutic Response in an Aggressive Rat C6 Glioma Model Treated with a Highly Effective Novel agent

Primary: Preclinical Animal & in vitro MR - Biology, Models, Methods
Secondary: Neuro - Tumors
504-04-010 · Cancer Imaging and Spectroscopy · Wednesday, 13 May, 4:00 PM–5:50 PM · Ballroom East
Keywords: C6 glioma
Accepted
Abbas Khojasteh1, Ralph Hurd2, Laura J Pisani2, Meng Gu2, Phil M Adamson3, Nikita Mishra4, Niven Narain5, Lawrence Recht6, Daniel M Spielman 7
1Neurology and Neurological Sciences, Stanford Medicine, Stanford, United States of America
2Department of Radiology, Stanford University, Stanford, United States of America
3Department of Electrical Engineering, Stanford University, Stanford, United States of America
4Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
5BPGbio (Waltham, MA), Waltham, United States of America
6Department of Neurology and Neurological Sciences, Stanford University, Stanford, United States of America
7Department of Radiology, Stanford Medicine, Stanford, United States of America
Presenting Author: Daniel M Spielman

Synopsis

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References

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2. Giakoumettis D, Kritis A, Foroglou N. C6 cell line: the gold standard in glioma research. Hippokratia. Jul–Sep 2018;22(3):105–112.
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4. Pournajaf S, Afsordeh N, Pourgholami MH. In vivo C6 glioma models: an update and a guide toward a more effective preclinical evaluation of potential anti-glioblastoma drugs. Rev Neurosci. Feb 26 2024;35(2):183–195. doi:10.1515/revneuro-2023-0067 [doi]
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6. Garg S, Swaminathan V, Dhavala S, Kiebish MA, Sarangarajan R, Narain NR. CoQ(10) selective miscibility and penetration into lipid monolayers with lower lateral packing density. Biochim Biophys Acta Biomembr. Jul 2017;1859(7):1173–1179. doi:10.1016/j.bbamem.2017.03.021 [doi]
7. Sun J, Patel CB, Jang T, et al. High levels of ubidecarenone (oxidized CoQ(10)) delivered using a drug-lipid conjugate nanodispersion (BPM31510) differentially affect redox status and growth in malignant glioma versus non-tumor cells. Sci Rep. Aug 17 2020;10(1):13899. doi:10.1038/s41598-020-70969-0 [doi]
8. Remy C, Fouilhe N, Barba I, et al. Evidence that mobile lipids detected in rat brain glioma by 1H nuclear magnetic resonance correspond to lipid droplets. Cancer Res. Feb 1 1997;57(3):407–14.
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http://echo.ismrm.org/p/ISMRM2026/504-04-010