Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
368-01-016 ISMRM Abstract

Low-field, high-gradient diffusion NMR on in vivo mouse brain

Primary: Physics & Engineering - Low-Field MRI
Secondary: Diffusion - Microstructure
368-01-016 · Registration, Atlases, and Motion · Monday, 11 May, 8:20 AM–9:15 AM · Digital Posters Row I
Keywords: Preclinical Gradients New Devices Restricted diffusion Single-side MRI
Accepted
Nathan H Williamson 1, Rea Ravin2,3, Natalia Gudino4, Emily R Long5, Teddy X Cai3, Peter J Basser3,6,7
1The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, United States of America
2Celoptics, Rockville, United States of America
3Section on Quantitative Imaging and Tissue Sciences (SQITS), Eunice Kennedy Shriver - National Institute of Child Health and Human Development (NICHD), Bethesda, United States of America
4MRI Engineering Team (MRIEngT), Laboratory of Functional and Molecular Imaging, NINDS, NIH, Bethesda, United States of America
5Radiology and Bioengineering, Uniformed Services University of the Health Sciences, Bethesda, United States of America
61Section on Quantitative Imaging and Tissue Sciences (SQITS), Eunice Kennedy Shriver - National Institute of Child Health and Human Development (NICHD), Bethesda, United States of America
7National Institutes of Health, Bethesda, United States of America
Presenting Author: Nathan H Williamson

Synopsis

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References

1. Stejskal, Edward O., and John E. Tanner. "Spin diffusion measurements: spin echoes in the presence of a time‐dependent field gradient." The journal of chemical physics 42.1 (1965): 288-292. 10.1063/1.1695690 [doi]
2. Huang, Susie, et al. "Visualizing cortical laminar architecture in the living human brain using next-generation ultra-high-gradient diffusion MRI." Research Square (2025): rs-3.
3. Hahn, Erwin L. "Spin echoes." Physical review 80.4 (1950): 580. 10.1103/PhysRev.80.580 [doi]
4. McDaniel, Patrick C., et al. "The MR cap: a single‐sided MRI system designed for potential point‐of‐care limited field‐of‐view brain imaging." Magnetic resonance in medicine 82.5 (2019): 1946-1960.
5. Thomas, Dion G., et al. "Single-sided magnet system for quantitative MR relaxometry and preclinical in-vivo monitoring." IEEE Transactions on Biomedical Engineering 70.2 (2022): 671-680.
6. Eidmann, G., et al. "The NMR MOUSE, a mobile universal surface explorer." Journal of Magnetic Resonance, Series A 122.1 (1996): 104-109.
7. Williamson, Nathan H., et al. "Magnetic resonance measurements of cellular and sub-cellular membrane structures in live and fixed neural tissue." Elife 8 (2019): e51101.
8. Neuman, C. H. "Spin echo of spins diffusing in a bounded medium." The Journal of Chemical Physics 60.11 (1974): 4508-4511.
9. Hurlimann, M. D., et al. "Spin echoes in a constant gradient and in the presence of simple restriction." Journal of Magnetic Resonance, Series A 113.2 (1995): 260-264.
10. Williamson, Nathan H., et al. "Low-field, high-gradient NMR shows diffusion contrast consistent with localization or motional averaging of water near surfaces." Magnetic Resonance Letters 3.2 (2023): 90-107.
11. Afzali, Maryam, et al. "Cumulant Expansion with Localization: A new representation of the diffusion MRI signal." Frontiers in Neuroimaging 1 (2022): 958680.
12. Lee, Hong-Hsi, et al. "Localization regime of diffusion in human gray matter on a high-gradient MR system: sensitivity to soma size." International Society for Magnetic Resonance in Medicine Annual Meeting. 2021.
13. Aird-Rossiter, Charlie, et al. "Decoding Gray Matter: large-scale analysis of brain cell morphometry to inform microstructural modeling of diffusion MR signals." arXiv preprint arXiv:2501.02100 (2025).

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/368-01-016